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dc.contributor.authorTripathi, Pragya
dc.contributor.authorRomanini, Michela
dc.contributor.authorTamarit Mur, José Luis
dc.contributor.authorMacovez, Roberto
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.date.accessioned2016-01-13T10:20:24Z
dc.date.available2016-11-30T01:30:24Z
dc.date.issued2015-11-10
dc.identifier.citationTripathi, P., Romanini, M., Tamarit, J. Ll., Macovez, R. Collective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic. "International journal of pharmaceutics", 10 Novembre 2015, vol. 495, núm. 1, p. 420-427.
dc.identifier.issn0378-5173
dc.identifier.urihttp://hdl.handle.net/2117/81334
dc.description.abstractWe employ dielectric spectroscopy to monitor the relaxation dynamics and crystallization kinetics of the Biclotymol antiseptic in its amorphous phase. The glass transition temperature of the material as determined by dielectric spectroscopy is Tg=290±1K. The primary (a) relaxation dynamics is observed to follow a Vogel-Fulcher-Tammann temperature dependence, with a kinetic fragility index m=86±13, which classifies Biclotymol as a relatively fragile glass former. A secondary relaxation is also observed, corresponding to an intramolecular dynamic process of the non-rigid Biclotymol molecule. The crystallization kinetics, measured at four different temperatures above the glass transition temperature, follows an Avrami behavior with exponent virtually equal to n=2, indicating one-dimensional crystallization into needle-like crystallites, as experimentally observed, with a time-constant nucleation rate. The activation barrier for crystallization is found to be Ea=115±22kJmol(-1)
dc.format.extent8 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Física
dc.subject.lcshStability
dc.subject.lcshAmorphous semiconductors
dc.subject.otheramorphous
dc.subject.otherbiclotymol
dc.subject.otherdipolar relaxation
dc.subject.othercrystallization kinetics
dc.subject.otheravrami law
dc.subject.otherstability
dc.subject.otherkohlrausch-williams-watts
dc.subject.otherdomain havriliak-negami
dc.subject.othermolecular mobility
dc.subject.otherphysical stability
dc.subject.otherthermodynamic quantities
dc.subject.othersecondary relaxations
dc.subject.otherglass-transition
dc.subject.otherstate
dc.subject.otherwater
dc.subject.othertime
dc.titleCollective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic
dc.typeArticle
dc.subject.lemacSemiconductors amorfs
dc.contributor.groupUniversitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
dc.identifier.doi10.1016/j.ijpharm.2015.09.012
dc.rights.accessOpen Access
local.identifier.drac17238934
dc.description.versionPostprint (author's final draft)
local.citation.authorTripathi, P.; Romanini, M.; Tamarit, J. Ll.; Macovez, R.
local.citation.publicationNameInternational journal of pharmaceutics
local.citation.volume495
local.citation.number1
local.citation.startingPage420
local.citation.endingPage427


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