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dc.contributor.authorAlonso López, Joan Francesc
dc.contributor.authorMañanas Villanueva, Miguel Ángel
dc.contributor.authorRomero Lafuente, Sergio
dc.contributor.authorHoyer, Dirk
dc.contributor.authorRiba Ruiz, Jordi-Roger
dc.contributor.authorBarbanoj, Manel J.
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.date.accessioned2010-07-07T13:49:59Z
dc.date.available2010-07-07T13:49:59Z
dc.date.created2010-03
dc.date.issued2010-03
dc.identifier.citationAlonso, J. [et al.]. Drug effect on EEG connectivity assessed by linear and nonlinear couplings. "Human brain mapping", Març 2010, vol. 31, núm. 3, p. 487-497.
dc.identifier.issn1065-9471
dc.identifier.urihttp://hdl.handle.net/2117/8057
dc.description.abstractQuantitative analysis of human electroencephalogram (EEG) is a valuable method for evaluating psychopharmacological agents. Although the effects of different drug classes on EEG spectra are already known, interactions between brain locations remain unclear. In this work, cross mutual information function and appropriate surrogate data were applied to assess linear and nonlinear couplings between EEG signals. The main goal was to evaluate the pharmacological effects of alprazolam on brain connectivity during wakefulness in healthy volunteers using a cross-over, placebo-controlled design. Eighty-five pairs of EEG leads were selected for the analysis, and connectivity was evaluated inside anterior, central, and posterior zones of the scalp. Connectivity between these zones and interhemispheric connectivity were also measured. Results showed that alprazolam induced significant changes in EEG connectivity in terms of information transfer in comparison with placebo. Trends were opposite depending on the statistical characteristics: decreases in linear connectivity and increases in nonlinear couplings. These effects were generally spread over the entire scalp. Linear changes were negatively correlated, and nonlinear changes were positively correlated with drug plasma concentrations; the latter showed higher correlation coefficients. The use of both linear and nonlinear approaches revealed the importance of assessing changes in EEG connectivity as this can provide interesting information about psychopharmacological effects.
dc.format.extent11 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
dc.subjectÀrees temàtiques de la UPC::Informàtica::Automàtica i control
dc.subject.lcshAlprazolam
dc.subject.lcshBenzodiazepines
dc.subject.lcshDrugs--Physiological effect
dc.subject.lcshElectroencephalography
dc.titleDrug effect on EEG connectivity assessed by linear and nonlinear couplings
dc.typeArticle
dc.subject.lemacDrogues -- Efectes fisiològics
dc.subject.lemacElectroencefalografia
dc.contributor.groupUniversitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics
dc.identifier.doi10.1002/hbm.20881
dc.relation.publisherversionhttp://www3.interscience.wiley.com/journal/122675268/abstract?CRETRY=1&SRETRY=0
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac2201328
dc.description.versionPostprint (published version)
local.citation.authorAlonso, J.; Mañanas, M.; Romero, S.; Hoyer, D.; Riba, J.; Barbanoj, M.
local.citation.publicationNameHuman brain mapping
local.citation.volume31
local.citation.number3
local.citation.startingPage487
local.citation.endingPage497


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