Mostra el registre d'ítem simple
Drug effect on EEG connectivity assessed by linear and nonlinear couplings
dc.contributor.author | Alonso López, Joan Francesc |
dc.contributor.author | Mañanas Villanueva, Miguel Ángel |
dc.contributor.author | Romero Lafuente, Sergio |
dc.contributor.author | Hoyer, Dirk |
dc.contributor.author | Riba Ruiz, Jordi-Roger |
dc.contributor.author | Barbanoj, Manel J. |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial |
dc.date.accessioned | 2010-07-07T13:49:59Z |
dc.date.available | 2010-07-07T13:49:59Z |
dc.date.created | 2010-03 |
dc.date.issued | 2010-03 |
dc.identifier.citation | Alonso, J. [et al.]. Drug effect on EEG connectivity assessed by linear and nonlinear couplings. "Human brain mapping", Març 2010, vol. 31, núm. 3, p. 487-497. |
dc.identifier.issn | 1065-9471 |
dc.identifier.uri | http://hdl.handle.net/2117/8057 |
dc.description.abstract | Quantitative analysis of human electroencephalogram (EEG) is a valuable method for evaluating psychopharmacological agents. Although the effects of different drug classes on EEG spectra are already known, interactions between brain locations remain unclear. In this work, cross mutual information function and appropriate surrogate data were applied to assess linear and nonlinear couplings between EEG signals. The main goal was to evaluate the pharmacological effects of alprazolam on brain connectivity during wakefulness in healthy volunteers using a cross-over, placebo-controlled design. Eighty-five pairs of EEG leads were selected for the analysis, and connectivity was evaluated inside anterior, central, and posterior zones of the scalp. Connectivity between these zones and interhemispheric connectivity were also measured. Results showed that alprazolam induced significant changes in EEG connectivity in terms of information transfer in comparison with placebo. Trends were opposite depending on the statistical characteristics: decreases in linear connectivity and increases in nonlinear couplings. These effects were generally spread over the entire scalp. Linear changes were negatively correlated, and nonlinear changes were positively correlated with drug plasma concentrations; the latter showed higher correlation coefficients. The use of both linear and nonlinear approaches revealed the importance of assessing changes in EEG connectivity as this can provide interesting information about psychopharmacological effects. |
dc.format.extent | 11 p. |
dc.language.iso | eng |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
dc.subject | Àrees temàtiques de la UPC::Informàtica::Automàtica i control |
dc.subject.lcsh | Alprazolam |
dc.subject.lcsh | Benzodiazepines |
dc.subject.lcsh | Drugs--Physiological effect |
dc.subject.lcsh | Electroencephalography |
dc.title | Drug effect on EEG connectivity assessed by linear and nonlinear couplings |
dc.type | Article |
dc.subject.lemac | Drogues -- Efectes fisiològics |
dc.subject.lemac | Electroencefalografia |
dc.contributor.group | Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics |
dc.identifier.doi | 10.1002/hbm.20881 |
dc.relation.publisherversion | http://www3.interscience.wiley.com/journal/122675268/abstract?CRETRY=1&SRETRY=0 |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 2201328 |
dc.description.version | Postprint (published version) |
local.citation.author | Alonso, J.; Mañanas, M.; Romero, S.; Hoyer, D.; Riba, J.; Barbanoj, M. |
local.citation.publicationName | Human brain mapping |
local.citation.volume | 31 |
local.citation.number | 3 |
local.citation.startingPage | 487 |
local.citation.endingPage | 497 |
Fitxers d'aquest items
Aquest ítem apareix a les col·leccions següents
-
Articles de revista [1.397]
-
Articles de revista [70]