Life Sciences

Recent Submissions

  • Raising awareness of sex and gender bias in artificial intelligence and health 

    Buslón, Nataly; Cortés, Atia; Catuara Solarz, Silvina; Cirillo, Davide; Rementeria, Maria José (Frontiers Media, 2023)
    Article
    Open Access
    Historically, biomedical research has been led by and focused on men. The recent introduction of Artificial Intelligence (AI) in this area has further proven this practice to be discriminatory for other sexes and genders, ...

  • Molecular dynamics simulation of complexation between plasmid DNA and cationic peptides 

    Tsuchiya, Kousuke; Gimenez Dejoz, Joan; Numata, Keiji (Springer Nature, 2023)
    Article
    Open Access
    The elucidation of the process by which cationic peptides condense plasmid DNA (pDNA) is important for unraveling the mechanism of peptide/pDNA complex formation, which plays a vital role in gene delivery for the genetic ...

  • Identifying cellular cancer mechanisms through pathway-driven data integration 

    Windels, Sam F; Malod Dognin, Noël; Pržulj, Nataša (Oxford University Press, 2022)
    Article
    Open Access
    Motivation Cancer is a genetic disease in which accumulated mutations of driver genes induce a functional reorganization of the cell by reprogramming cellular pathways. Current approaches identify cancer pathways as those ...

  • A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma 

    Gureghian, Vincent; Herbst, Hailee; Kozar, Ines; Mihajlovic, Katarina; Malod-Dognin, Noël; Ceddia, Gaia; Pržulj, Nataša (Springer Nature, 2023)
    Article
    Open Access
    Therapy Induced Senescence (TIS) leads to sustained growth arrest of cancer cells. The associated cytostasis has been shown to be reversible and cells escaping senescence further enhance the aggressiveness of cancers. ...

  • A functional analysis of omic network embedding spaces reveals key altered functions in cancer 

    Doria Belenguer, Sergio; Xenos, Alexandros; Ceddia, Gaia; Malod Dognin, Noël; Pržulj, Nataša (Oxford University Press, 2023)
    Article
    Open Access
    Abstract Motivation Advances in omics technologies have revolutionized cancer research by producing massive datasets. Common approaches to deciphering these complex data are by embedding algorithms of molecular interaction ...

  • Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome 

    Salz, Lucia; Seitz, Alexander; Schäfer, Daniel; Franzen, Julia; Holzer, Tatjana; Garcia Prieto, Carlos A.; Bürger, Iris; Hardt, Olaf; Esteller, Manel; Wagner, Wolfgang (Springer Nature, 2023)
    Article
    Open Access
    Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of hematological malignancies. Manufacturing of these cellular products includes culture expansion procedures, which may affect cellular integrity ...

  • Insights into peculiar fungal LPMO family members holding a short C-terminal sequence reminiscent of phosphate binding motifs 

    Reyre, Jean-Lou; Grisel, Sacha; Haon, Mireille; Xiang, Ruite; Gaillard, Jean-Charles; Armengaud, Jean; Guallar, Victor; Margeot, Antoine; Arragain, Simon; Berrin, Jean-Guy; Bissaro, Bastien (Nature Research, 2023)
    Article
    Open Access
    Lytic polysaccharide monooxygenases (LPMOs) are taxonomically widespread copper-enzymes boosting biopolymers conversion (e.g. cellulose, chitin) in Nature. White-rot Polyporales, which are major fungal wood decayers, may ...

  • Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens 

    Mixão, Verónica; Nuñez Rodriguez, Juan Carlos; Olmo, Valentina del; Ksiezopolska, Ewa; Saus, Ester; Boekhout, Teun; Gacser, Attila; Gabaldon, Toni (BioMed Central (BMC), 2023)
    Article
    Open Access
    Background Hybrids are chimeric organisms with highly plastic heterozygous genomes that may confer unique traits enabling the adaptation to new environments. However, most evolutionary theory frameworks predict that the ...

  • Maturases and Group II Introns in the Mitochondrial Genomes of the Deepest Jakobid Branch 

    Galindo, Luis Javier; Prokina, Kristina; Torruella, Guifré; López García, Purificación; Moreira, David (Oxford University Press, 2023)
    Article
    Open Access
    Ophirinina is a recently described suborder of jakobid protists (Excavata) with only one described species to date, Ophirina amphinema. Despite the acquisition and analysis of massive transcriptomic and mitogenomic sequence ...

  • Systematic characterization of regulatory variants of blood pressure genes 

    Oliveros, Winona; Delfosse, Kate; Lato, Daniella F.; Kiriakopulos, Katerina; Mokhtaridoost, Milad; Melé, Marta (Cell Press, 2023)
    Article
    Open Access
    High blood pressure (BP) is the major risk factor for cardiovascular disease. Genome-wide association studies have identified genetic variants for BP, but functional insights into causality and related molecular mechanisms ...

  • Whole genome analysis of two sympatric human Mansonella: Mansonella perstans and Mansonella sp “DEUX” 

    Rodi, Miriam; Gross, Caspar; Sandri, Thaisa Lucas; Berner, Lilith; Marcet Houben, Marina; Gabaldón, Toni (Frontiers, 2023)
    Article
    Open Access
    IntroductionMansonella species are filarial parasites that infect humans worldwide. Although these infections are common, knowledge of the pathology and diversity of the causative species is limited. Furthermore, the lack ...

  • The FAIR Cookbook - the essential resource for and by FAIR doers 

    Rocca Serra, Philippe; Gu, Wei; Ioannidis, Vassilios; Abbassi Daloii, Tooba; Capella Gutierrez, Salvador; Marin del Piico, Eva (Nature Research, 2023)
    Article
    Open Access
    The notion that data should be Findable, Accessible, Interoperable and Reusable, according to the FAIR Principles, has become a global norm for good data stewardship and a prerequisite for reproducibility. Nowadays, FAIR ...

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