Recent Submissions

  • Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells 

    Pekmezovic, Marina; Hovhannisyan, Hrant; Gresnigt, Mark S.; Iracane, Elise; Oliveira Pacheco, João; Siscar Lewin, Sofía; Seemann, Eric; Qualmann, Britta; Kalkreuter, Till; Müller, Sylvia; Kamradt, Thomas; Mogavero, Selene; Brunke, Sascha; Butler, Geraldine; Gabaldón, Toni; Hube, Bernhard (Springer Nature, 2021)
    Article
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    Vaginal candidiasis is an extremely common disease predominantly caused by four phylogenetically diverse species: Candida albicans; Candida glabrata; Candida parapsilosis; and Candida tropicalis. Using a time course infection ...
  • A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome 

    Khannous Lleiffe, Olfat; Willis, Jesse R.; Saus, Ester; Cabrera Aguilera, Ignacio; Almendros, Isaac; Farré, Ramon; Gozal, David; Farré, Nuria; Gabaldón, Toni (MDPI, 2021)
    Article
    Open Access
    Heart failure (HF) is a common condition associated with a high rate of hospitalizations and adverse outcomes. HF is characterized by impairments of either the cardiac ventricular filling, ejection of blood capacity or ...
  • Unraveling the molecular basis of host cell receptor usage in SARS-CoV-2 and other human pathogenic β-CoVs 

    Pontes, Camila; Ruiz Serra, Victoria; Lepore, Rosalba; Valencia, Alfonso (Elsevier, 2021)
    Article
    Open Access
    The recent emergence of the novel SARS-CoV-2 in China and its rapid spread in the human population has led to a public health crisis worldwide. Like in SARS-CoV, horseshoe bats currently represent the most likely candidate ...
  • Probabilistic graphlets capture biological function in probabilistic molecular networks 

    Doria Belenguer, Sergio; Youssef, Markus K.; Böttcher, René; Malod-Dognin, Noël; Przulj, Natasa (Oxford University Press, 2020)
    Article
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    Motivation Molecular interactions have been successfully modeled and analyzed as networks, where nodes represent molecules and edges represent the interactions between them. These networks revealed that molecules with ...
  • Artificial Intelligence–Aided Precision Medicine for COVID-19: Strategic Areas of Research and Development 

    Santus, Enrico; Marino, Nicola; Cirillo, Davide; Chersoni, Emmanuele; Montagud, Arnau; Santuccione Chadha, Antonella; Valencia, Alfonso; Hughes, Kevin; Lindvall, Charlotta (JMIR Publications, 2021)
    Article
    Open Access
    Artificial intelligence (AI) technologies can play a key role in preventing, detecting, and monitoring epidemics. In this paper, we provide an overview of the recently published literature on the COVID-19 pandemic in four ...
  • Artificial intelligence in cancer research: learning at different levels of data granularity 

    Cirillo, Davide; Nuñez Carpintero, Iker; Valencia, Alfonso (Wiley, 2021)
    Article
    Open Access
    From genome-scale experimental studies to imaging data, behavioral footprints, and longitudinal healthcare records, the convergence of big data in cancer research and the advances in Artificial Intelligence (AI) is paving ...
  • Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans 

    Priest, Shelby J.; Coelho, Marco A.; Mixão, Verónica; Applen Clancey, Shelly; Xu, Yitong; Sun, Sheng; Gabaldon, Toni; Heitman, Joseph (PLOS, 2021)
    Article
    Open Access
    Hybridization has resulted in the origin and variation in extant species, and hybrids continue to arise despite pre- and post-zygotic barriers that limit their formation and evolutionary success. One important system that ...
  • Comprehensive insights into the production of long chain aliphatic aldehydes using a copper-radical alcohol oxidase as biocatalyst 

    Ribeaucourt, David; Bissaro, Bastien; Guallar, Victor; Yemloul, Mehdi; Haon, Mireille; Grisel, Sacha; Alphand, Véronique; Brumer, Harry; Lambert, Fanny; Berrin, Jean-Guy; Lafond, Mickael (American Chemical Society, 2021)
    Article
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    The oxidation of alcohols is a cornerstone reaction in chemistry, notably in the flavor and fragrance industry where long-chain aliphatic aldehydes are major odorant compounds. In a context where greener alternatives are ...
  • The eTRANSAFE project on translational safety assessment through integrative knowledge management: achievements and perspectives 

    Pognan, François; Steger-Hartmann, Thomas; Díaz, Carlos; Blomberg, Niklas; Bringezu, Frank; Briggs, Katharine; Callegaro, Giulia; Capella Gutiérrez, Salvador; Centeno, Emilio; Corvi, Javier; Drew, Philip; Drewe, William C.; Fernández González, Jose María; Furlong, Laura I.; Guney, Emre; Kors, Jan A.; Mayer, Miguel Angel; Pastor, Manuel; Piñero, Janet; Ramírez-Anguita, Juan Manuel; Ronzano, Francesco; Rowell, Philip; Saüch-Pitarch, Josep; Valencia, Alfonso; Water, Bob van de; Lei, Johan van der; Mulligen, Erik van; Sanz, Ferran (MDPI, 2021)
    Article
    Open Access
    eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety ...
  • Artificial Intelligence–Aided Precision Medicine for COVID-19: Strategic Areas of Research and Development 

    Santus, Enrico; Marino, Nicola; Cirillo, Davide; Chersoni, Emmanuele; Montagud, Arnau; Santuccione Chadha, Antonella; Valencia, Alfonso; Hughes, Kevin; Lindvall, Charlotta (JMIR Publications, 2021-03)
    Article
    Open Access
    Artificial intelligence (AI) technologies can play a key role in preventing, detecting, and monitoring epidemics. In this paper, we provide an overview of the recently published literature on the COVID-19 pandemic in four ...
  • Computationally driven rational design of substrate promiscuity on serine ester hydrolases 

    Roda, Sergi; Fernandez Lopez, Laura; Cañadas, Rubén; Santiago, Gerard; Ferrer, Manuel; Guallar, Victor (American Chemical Society, 2021)
    Article
    Restricted access - publisher's policy
    Enzymes with a broad substrate specificity are of great interest both at the basic and applied level. Understanding the main parameters that make an enzyme substrate ambiguous could be thus important not only for their ...
  • Converses al voltant de la intel·ligència artificial en clau catalana 

    Ruiz Costa-Jussà, Marta; Melero Nogues, Maite (2020-12)
    Article
    Open Access
    La intel·ligència artificial mou milions d’euros i ocupa una part important de les agendes polítiques i estratègiques dels governs. En aquest article reflexionem sobre aquest concepte difús i ho fem a través de tres ...

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