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dc.contributor.authorLee, So-Youn
dc.contributor.authorYun, Hyung-Mun
dc.contributor.authorPérez Antoñanzas, Román
dc.contributor.authorGallinetti, Sara
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.authorChoi, Seong-Jun
dc.contributor.authorKim, Hae-Won
dc.contributor.authorKim, Eun-Cheol
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.date.accessioned2015-12-10T10:20:50Z
dc.date.available2015-12-10T10:20:50Z
dc.date.issued2015-01-01
dc.identifier.citationLee, S., Yun, H., Perez, R., Gallinetti, S., Ginebra, M.P., Choi, S., Kim, H-W., Kim, E. Nanotopological-tailored calcium phosphate cements for the odontogenic stimulation of human dental pulp stem cells through integrin signaling. "RSC Advances", 01 Gener 2015, vol. 5, núm. 78, p. 63363-63371.
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/2117/80372
dc.description.abstractCalcium phosphate cements (CPCs) are a unique class of inorganic injectables attractive for the repair and regeneration of hard tissues. Tailoring the crystallite properties of CPC, particularly to represent nanotopological features, is favorable for stimulating biological reactions. Nanotopological tailoring has recently been achieved on CPCs by simply modulating the sizes of the initial particles. Herein, we aim to investigate the effects of nanotopological-tailored CPCs on the odontogenic differentiation of stem cells derived from human dental pulp (HDPSCs) as well as on their implicated signal pathways. The initial adhesion of the cells was substantially higher on nano-CPCs than on micro-CPCs. A series of indications of odontogenesis, including alkaline phosphatase activity and gene expressions (dentin matrix protein-1, dentin sialophosphoprotein, osteocalcin, ostepontin, and bone sialoprotein) were significantly stimulated on the nano-CPC in comparison to the micro-CPC. Furthermore, the integrin downstream pathways of the cells, including FAK, paxillin, Akt, MAPK, and NF-kappa B, were highly activated on the nano-CPC with respect to those on the micro-CPCs. Collectively, the nanotopological CPCs significantly enhance the odontogenic differentiation of HDPSCs when compared to conventional micro-CPCs through the integrin-associated signaling pathways, which implies that the nanotopological CPCs may be more potent in the repair and regeneration of dentin-pulp complex tissues.
dc.format.extent9 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshTissue engineering
dc.subject.lcshBiomedical materials
dc.subject.lcshBone cements
dc.subject.otherOdontoblastic differentiation
dc.subject.otherosteogenic differentiation
dc.subject.otherparticle-size
dc.subject.othertissue
dc.subject.otherpathway
dc.subject.otherbone
dc.subject.otherexpression
dc.subject.otherdelivery
dc.titleNanotopological-tailored calcium phosphate cements for the odontogenic stimulation of human dental pulp stem cells through integrin signaling
dc.typeArticle
dc.subject.lemacCiments ossis
dc.subject.lemacMaterials biomèdics
dc.subject.lemacEnginyeria de teixits
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1039/c5ra11564g
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C5RA11564G#!divAbstract
dc.rights.accessOpen Access
drac.iddocument16889703
dc.description.versionPostprint (author's final draft)
dc.contributor.covenanteeTan'guk Taehakkyo
upcommons.citation.authorLee, S., Yun, H., Perez, R., Gallinetti, S., Ginebra, M.P., Choi, S., Kim, H-W., Kim, E.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameRSC Advances
upcommons.citation.volume5
upcommons.citation.number78
upcommons.citation.startingPage63363
upcommons.citation.endingPage63371


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