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Nanotopological-tailored calcium phosphate cements for the odontogenic stimulation of human dental pulp stem cells through integrin signaling

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Posprint, Accepted paper (581,6Kb)
 
10.1039/c5ra11564g
 
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hdl:2117/80372

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Lee, So-Youn
Yun, Hyung-Mun
Pérez Antoñanzas, Román
Gallinetti, Sara
Ginebra Molins, Maria PauMés informacióMés informacióMés informació
Choi, Seong-Jun
Kim, Hae-Won
Kim, Eun-Cheol
CovenanteeTan'guk Taehakkyo
Document typeArticle
Defense date2015-01-01
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Calcium phosphate cements (CPCs) are a unique class of inorganic injectables attractive for the repair and regeneration of hard tissues. Tailoring the crystallite properties of CPC, particularly to represent nanotopological features, is favorable for stimulating biological reactions. Nanotopological tailoring has recently been achieved on CPCs by simply modulating the sizes of the initial particles. Herein, we aim to investigate the effects of nanotopological-tailored CPCs on the odontogenic differentiation of stem cells derived from human dental pulp (HDPSCs) as well as on their implicated signal pathways. The initial adhesion of the cells was substantially higher on nano-CPCs than on micro-CPCs. A series of indications of odontogenesis, including alkaline phosphatase activity and gene expressions (dentin matrix protein-1, dentin sialophosphoprotein, osteocalcin, ostepontin, and bone sialoprotein) were significantly stimulated on the nano-CPC in comparison to the micro-CPC. Furthermore, the integrin downstream pathways of the cells, including FAK, paxillin, Akt, MAPK, and NF-kappa B, were highly activated on the nano-CPC with respect to those on the micro-CPCs. Collectively, the nanotopological CPCs significantly enhance the odontogenic differentiation of HDPSCs when compared to conventional micro-CPCs through the integrin-associated signaling pathways, which implies that the nanotopological CPCs may be more potent in the repair and regeneration of dentin-pulp complex tissues.
CitationLee, S., Yun, H., Perez, R., Gallinetti, S., Ginebra, M.P., Choi, S., Kim, H-W., Kim, E. Nanotopological-tailored calcium phosphate cements for the odontogenic stimulation of human dental pulp stem cells through integrin signaling. "RSC Advances", 01 Gener 2015, vol. 5, núm. 78, p. 63363-63371. 
URIhttp://hdl.handle.net/2117/80372
DOI10.1039/c5ra11564g
ISSN2046-2069
Publisher versionhttp://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C5RA11564G#!divAbstract
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  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica - Articles de revista [960]
  • BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits - Articles de revista [484]
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