El GRBIO és un grup interdisciplinari amb interessos diversos tant metodològics com aplicats amb una base comuna que és l'aplicació rigorosa de l'estadística a problemes suscitats a les Ciències de la Vida i de la Salut. Les activitats científiques les agrupem en tres àmbits:
1) Assajos clínics: aportacions metodològiques en les fases de disseny i modelat estadístic;
2) Anàlisi integrativa de dades òmiques: mètodes estadístics multivariants i de "machine learning";
3) Desenvolupament d'eines estadístiques i informàtiques per l'explotació dels resultats de la recerca biomèdica.
Mencionem també les contribucions a l'anàlisi i representació de dades multivariants, a l'anàlisi de dades de supervivència amb censura en un interval, a l'optimització del disseny de fàrmacs amb simulació i a la resolució de problemes aplicats en camps com VIH/SIDA, oncologia, neurociències, cardiologia o immunologia.

Research Group in Biostatistics and Bioinformatics (GRBIO) combines researchers with solid basis in statistics, good background in mathematics and/or computer science and significant knowledge of the scientific field of application in which we collaborate. GRBIO aims to address interdisciplinary problems by merging Biostatistics and Bioinformatics knowledge and to make relevant scientific contributions on health areas where closer collaboration is needed.

Research Group in Biostatistics and Bioinformatics (GRBIO) combines researchers with solid basis in statistics, good background in mathematics and/or computer science and significant knowledge of the scientific field of application in which we collaborate. GRBIO aims to address interdisciplinary problems by merging Biostatistics and Bioinformatics knowledge and to make relevant scientific contributions on health areas where closer collaboration is needed.

Enviaments recents

  • Survival analysis with censored data: a further twist on ignorability conditions 

    Oller Piqué, Ramón; Gómez Melis, Guadalupe (Taylor & Francis Group, 2024-02-04)
    Article
    Accés obert
    A key assumption for the application of methods concerning censored data is that the random nature of the censoring mechanism should be ignorable when making likelihood-based inferences. The constant-sum property is an ...
  • Burnout in residents during the first wave of the COVID-19 pandemic: a systematic review and meta-analysis 

    Navinés, Ricard; Olivé, Victòria; Hidalgo Mazzei, Diego; Langohr, Klaus; Vieta, E.; Martín-Santos, Rocío (Frontiers Media SA, 2024-01-24)
    Article
    Accés obert
    The high prevalence of burnout in resident physicians is expected to have increased as a result of the expansion of the pandemic. We conducted a systematic review with a meta-analysis of studies conducted during the first ...
  • Mixture-based clustering with covariates for ordinal responses 

    Preedalikit, Kemmawadee; Fernández Martínez, Daniel; Liu, Ivy; McMillan, Louise; Nai Ruscone, Marta; Costilla, Roy (2023)
    Text en actes de congrés
    Accés restringit per política de l'editorial
    Existing methods can perform likelihood-based clustering on a multivariate data matrix of ordinal responses, using finite mixtures to cluster the rows and columns of the matrix. Those models can incorporate the main effects ...
  • Gut microbiome signatures linked to HIV-1 reservoir size and viremia control 

    Borgognone, Alessandra; Noguera Julian, Marc; Oriol, Bruna; Noël Romas, Laura; Ruiz Riol, Marta; Guillen, Yolanda; Parera, Mariona; Casadellà, Maria; Duran, Clara; Puertas Castro, Maria C.; Català Moll, Francesc; De Leon, Marlon; Knodel, Samantha; Pérez Álvarez, Nuria (2022-04-11)
    Article
    Accés obert
    Background The potential role of the gut microbiome as a predictor of immune-mediated HIV-1 control in the absence of antiretroviral therapy (ART) is still unknown. In the BCN02 clinical trial, which combined the MVA.HIVconsv ...
  • Heterogeneity of treatment response to beta-blockers in the treatment of portal hypertension: a systematic review 

    Alsaeid, Mohammad; Sung, Shuen; Bai, Wayne; Tam, Matthew; Wong, Yu Jun; Cortés Martínez, Jordi; Cobo Valeri, Erik; González Alastrué, José Antonio; González Abraldes, Juan (2024-02)
    Article
    Accés obert
    Background: It has been suggested that a relevant proportion of patients do not respond to nonselective beta-blockers (NSBB)s, which raises questions regarding the need for individualized therapy. The existence of potential ...
  • One-dimensional mixture-based clustering for ordinal responses 

    Preedalikit, Kemmawadee; Fernández Martínez, Daniel; Liu, Ivy; McMillan, Louise; Nai Ruscone, Marta; Costilla, Roy (2023)
    Text en actes de congrés
    Accés restringit per política de l'editorial
    Existing methods can perform likelihood-based clustering on a multivariate data matrix of ordinal responses, using finite mixtures to cluster the rows and columns of the matrix. Those models can incorporate the main effects ...
  • Brealing through the traffic congestion: asynchronous time series data integration and XGBoost for accurate traffic density prediction 

    Garcia Climent, Eloi; Serrat Piè, Carles; Xhafa Xhafa, Fatos (Institute of Electrical and Electronics Engineers (IEEE), 2023)
    Text en actes de congrés
    Accés obert
  • Prevalence, progression, and management of advanced chronic kidney disease in a cohort of people living with HIV 

    Bonjoch Badia, Anna; Juega Mariño, Javier; Echeverria Liras, Patricia; Puig, Jordi; Pérez Álvarez, Nuria; Bonal, Jordi; Loste, Cora; Clotet, Bonaventura; Negredo Puigmal, Eugènia (2022-04-26)
    Article
    Accés restringit per política de l'editorial
  • Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study 

    Ramon Santos, Jose; Casadellà, Maria; Noguera Julian, Marc; Micán Rivera, Rafael; Domingo Pedrol, Pere; Antela, Antonio; Portilla, Joaquin; Sanz Sanz, Jesús; Montero Alonso, Marta; Navarro Mercade, Jordi; Masiá, Mar; Valcarce Pardeiro, Nieves; Pérez Álvarez, Nuria (2023-06-26)
    Article
    Accés obert
    Introduction: Second-generation integrase strand transfer inhibitors (INSTIs) are preferred treatment options worldwide, and dolutegravir (DTG) is the treatment of choice in resource-limited settings. Nevertheless, in some ...
  • Interval-censored covariates in regression models 

    Langohr, Klaus; Toloba López-Egea, Andrea; Gómez Melis, Guadalupe (TU Dortmund University, 2023)
    Comunicació de congrés
    Accés obert
    Interval-censored time-to-event data are common whenever the event of interest is a silent event that cannot be observed directly. Here, we present an estimation method for generalized linear models with interval-censored ...
  • Safety and efficacy of ApTOLL in patients with ischemic stroke undergoing endovascular treatment: a phase 1/2 randomized clinical trial 

    Hernández Jiménez, Macarena; Abad Santos, Francisco; Cotgreave, Ian; Gallego Pérez de Larraya, Jaime; Jilma, Bernd; Flores, Alan; Jovin, Tudor G.; Vivancos, José; Hernández Pérez, María; Molina Cateriano, Carlos; Montaner Villalonga, Joan; Casariego García, Joaquín; Dalsgaard, Mad; Liebeskind, David S.; Cobo Valeri, Erik; Castellanos Arboleda, Maria Isabel (2023-06-20)
    Article
    Accés restringit per política de l'editorial
    Importance ApTOLL is a TLR4 antagonist with proven preclinical neuroprotective effect and a safe profile in healthy volunteers. Objective To assess the safety and efficacy of ApTOLL in combination with endovascular treatment ...
  • Análisis estadístico de los factores de riesgo asociados a las patologías de la columna lumbar para la población empleada 

    Mena, Vanessa; Fernández Martínez, Daniel; Guevara, Patricia (Universidad Central del Ecuador, 2022-07-01)
    Article
    Accés obert
    Objetivo: Determinar los factores de riesgo de patologías lumbares en pacientes empleados y afiliados al sistema de salud, a partir de la exploración física, hábitos, antecedentes personales y factores de riesgo ...

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