El GRBIO és un grup interdisciplinari amb interessos diversos tant metodològics com aplicats amb una base comuna que és l'aplicació rigorosa de l'estadística a problemes suscitats a les Ciències de la Vida i de la Salut. Les activitats científiques les agrupem en tres àmbits:
1) Assajos clínics: aportacions metodològiques en les fases de disseny i modelat estadístic;
2) Anàlisi integrativa de dades òmiques: mètodes estadístics multivariants i de "machine learning";
3) Desenvolupament d'eines estadístiques i informàtiques per l'explotació dels resultats de la recerca biomèdica.
Mencionem també les contribucions a l'anàlisi i representació de dades multivariants, a l'anàlisi de dades de supervivència amb censura en un interval, a l'optimització del disseny de fàrmacs amb simulació i a la resolució de problemes aplicats en camps com VIH/SIDA, oncologia, neurociències, cardiologia o immunologia.

Research Group in Biostatistics and Bioinformatics (GRBIO) combines researchers with solid basis in statistics, good background in mathematics and/or computer science and significant knowledge of the scientific field of application in which we collaborate. GRBIO aims to address interdisciplinary problems by merging Biostatistics and Bioinformatics knowledge and to make relevant scientific contributions on health areas where closer collaboration is needed.

Research Group in Biostatistics and Bioinformatics (GRBIO) combines researchers with solid basis in statistics, good background in mathematics and/or computer science and significant knowledge of the scientific field of application in which we collaborate. GRBIO aims to address interdisciplinary problems by merging Biostatistics and Bioinformatics knowledge and to make relevant scientific contributions on health areas where closer collaboration is needed.

Recent Submissions

  • Design of trials with composite endpoints with the R package compAREdesign 

    Cortés Martínez, Jordi; Bofill Roig, Marta; Gómez Melis, Guadalupe (2022-11-04)
    Article
    Open Access
    Composite endpoints are widely used as primary endpoints in clinical trials. Designing trials with time-to-event endpoints can be particularly challenging because the proportional hazard assumption usually does not hold ...
  • SARS-Cov-2 incubation period according to vaccination status during the fifth COVID-19 wave in a tertiary-care center in Spain: a cohort study 

    Cortés Martínez, Jordi; Pak, Daewoo; Abelenda Alonso, Gabriela; Langohr, Klaus; Ning, Jing; Rombauts, Alexander; Colom Guerra, Mireia; Shen, Yu; Gómez Melis, Guadalupe (2022-11-09)
    Article
    Open Access
    Background: The incubation period of an infectious disease is defined as the elapsed time between the exposure to the pathogen and the onset of symptoms. Although both the mRNA-based and the adenoviral vector-based vaccines ...
  • Healthy aging and late-life depression in Europe: Does migration matter? 

    Bayés Marín, Ivet; Fernández Martínez, Daniel; Ayuso-Mateos, José Luis; Leonardi, Matilde; Tobiasz-Adamczyk, Beata; Koskinen, Seppo; Sánchez Niubó, Albert; Cristobal Narvaez, Paula (Frontiers Media SA, 2022-11-07)
    Article
    Open Access
    Background: There is limited research examining the impact of risk and protective factors on late-life depression using large population-based datasets, particularly those examining differences among older migrants and ...
  • Heterogeneity in response to MCT and psychoeducation: a feasibility study using latent class mixed models in first-episode psychosis 

    Ferrer-Quintero, Marta; Fernández Martínez, Daniel; López Carrilero, Raquel; Verdaguer Rodriguez, Marina; Garcia Mieres, Helena; Huerta Ramos, Elena; Gómez Benito, Juana; Peláez, Trini; Birulés Muntané, Irene; Barajas Velez, Ana Belen (2022-11)
    Article
    Open Access
    Metacognitive training (MCT) is an effective treatment for psychosis. Longitudinal trajectories of treatment response are unknown but could point to strategies to maximize treatment efficacy during the first episodes. This ...
  • Generalized Mantel–Haenszel estimators for simultaneous differential item functioning tests 

    Liu, Ivy; Suesse, Thomas; Harvey, Samuel; Yongqi Gu, Peter; Fernández Martínez, Daniel; Randal, John (2022-10-15)
    Article
    Open Access
    The Mantel–Haenszel estimator is one of the most popular techniques for measuring differential item functioning (DIF). A generalization of this estimator is applied to the context of DIF to compare items by taking the ...
  • BDNF and cortisol in the diagnosis of cocaine-induced depression 

    Fonseca, Francina; Mestre Pintó, Joan; Papaseit, Esther; Perez Maña, Clara; Langohr, Klaus; Farré, Magí; Torrens, Marta (Frontiers Media SA, 2022-03-15)
    Article
    Open Access
    Major depressive disorder (MDD) and cocaine use disorder (CUD) are related with disability and high mortality rates. The assessment and treatment of psychiatric comorbidity is challenging due to its high prevalence and its ...
  • Validation of direct cortical stimulation in presurgical evaluation of epilepsy 

    Ley, Miguelq; Principe, Alessandro; Langohr, Klaus; Zucca, Riccardo; Rocamora, Rodrigo (2022-05-01)
    Article
    Restricted access - publisher's policy
    Objective Direct cortical stimulation (DCS) is standard for intracranial presurgical evaluation in drug-resistant epilepsy (DRE). Few studies have reported levels of concordance between spontaneous seizure generators and ...
  • Males and females with first episode psychosis present distinct profiles of social cognition and metacognition 

    Ferrer-Quintero, Marta; Fernández Martínez, Daniel; López Carrilero, Raquel; Birulés Muntané, Irene; Barajas Velez, Ana Belen; Lorente Rovira, Esther; Luengo, Ana; Diaz Cutraro, Luciana; Verdaguer Rodriguez, Marina; Garcia Mieres, Helena (2022-07-08)
    Article
    Open Access
    Deficits in social cognition and metacognition impact the course of psychosis. Sex differences in social cognition and metacognition could explain heterogeneity in psychosis. 174 (58 females) patients with first-episode ...
  • Evaluation of metabolic changes in acute intermittent porphyria patients by targeted metabolomics 

    Gómez Gómez, Àlex; Aguilera Peiró, Paula; Langohr, Klaus; Casals Mercadal, Gregori; Pavón Solís, Cristina; Marcos del Aguila, Jose; To Figueras, Jordi; Pozo Mendoza, Oscar J. (2022-03-16)
    Article
    Open Access
    Acute intermittent porphyria (AIP) is an inherited rare hepatic disorder due to mutations within the hydroxymethylbilane gene. AIP patients with active disease overproduce aminolevulinic acid (ALA) and porphobilinogen (PBG) ...
  • Descripción de la supervivencia con indicadores numéricos y gráficos: conceptos básicos y errores que evitar 

    Gómez Melis, Guadalupe; Cortés Martínez, Jordi; Cobo Valeri, Erik (2022-02-15)
    Article
    Restricted access - publisher's policy
  • Effects of mixing energy drinks with alcohol on driving-related skills 

    Pérez Mañá, Clara; Mateus Rodríguez, Julián Andrés; Díaz Pellicer, Patricia; Pujadas, Mitona; Fonseca, Francina; Papaseit, Esther; Pujol Nuez, Jesus; Langohr, Klaus; De la Torre Fornell, Rafael (2021-09-02)
    Article
    Open Access
    Energy drinks (EDs) reduce sleepiness and fatigue and improve driving performance whereas alcohol does just the opposite. Although it is a trendy combination among young people, the effects of alcohol mixed with EDs on ...
  • Goodness-of-fit and generalized estimating equation methods for ordinal responses based on the stereotype model 

    Fernández Martínez, Daniel; McMillan, Louise; Arnold, Richard; Spiess, Martin; Liu, Ivy (MDPI AG, 2022-06-01)
    Article
    Open Access
    Background: Data with ordinal categories occur in many diverse areas, but methodologies for modeling ordinal data lag severely behind equivalent methodologies for continuous data. There are advantages to using a model ...

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