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Target trial emulation with multi-state model analysis to assess treatment effectiveness using clinical COVID-19 data
(Springer Nature, 2023-09-02)
Article
Open AccessBackground: Real-world observational data are an important source of evidence on the treatment effectiveness for patients hospitalized with coronavirus disease 2019 (COVID-19). However, observational studies evaluating ... -
Correspondence on “Electrocardiographic findings and prognostic values in patients hospitalised with COVID-19 in the World Heart Federation Global Study” by Pinto-Filho et al
(2023-02-14)
Article
Open AccessThe manuscript by Martins Pinto-Filho et al., a multicentre study on the prognostic value of electrocardiographic findings, was evaluated. However, certain critical issues were highlighted. First, the authors didn't verify ... -
An integrated mathematical model of the cardiovascular and respiratory response to exercise: Model-building and comparison with reported models
(2021-04-01)
Article
Open AccessThe use of physiological models in medicine allows the evaluation of new hypotheses, development of diagnosis and clinical treatment applications, and development of training and medical education tools, as well as medical ... -
Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021
(2023-06)
Article
Open AccessBackground Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global ... -
Rigorous performance assessment of the algorithms for resolving motor unit action potential superpositions
(2021-02-01)
Article
Open AccessIt is necessary to decompose the intra-muscular EMG signal to extract motor unit action potential (MUAP) waveforms and firing times. Some algorithms were proposed in the literature to resolve superimposed MUAPs, including ... -
The kappa opioid receptor and the sleep of reason: cortico-subcortical Imbalance following Salvinorin-A
(Oxford University Press, 2022-01-12)
Article
Open AccessBackground: The mechanisms through which kappa opioid receptor (KOR) agonists induce psychotomimetic effects are largely unknown, although the modulation of this receptor has attracted attention for its clinical use. In ... -
Developing non-laboratory cardiovascular risk assessment charts and validating laboratory and non-laboratory-based models
(Elsevier, 2021-09-02)
Article
Open AccessBackground: Developing simplified risk assessment model based on non-laboratory risk factors that could determine cardiovascular risk as accurately as laboratory-based one can be valuable, particularly in developing countries ... -
Fetal ECG extraction from maternal ECG using attention-based cycleGAN
(Institute of Electrical and Electronics Engineers (IEEE), 2022-02)
Article
Restricted access - publisher's policyA non-invasive fetal electrocardiogram (FECG) is used to monitor the electrical pulse of the fetal heart. Decomposing the FECG signal from the maternal ECG (MECG) is a blind source separation problem, which is hard due to ... -
Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study
(Springer Nature, 2023-05-07)
Article
Open AccessPURPOSE: The objective of this study was to quantitatively evaluate psychological and quality of life-related complications at three months following discharge in hospitalized coronavirus disease 2019 (COVID-19) patients ... -
A real-time and convex model for the estimation of muscle force from surface electromyographic signals in the upper and lower limbs
(Frontiers Media SA, 2023-02)
Article
Open AccessLow-volume lung injury encompasses local concentration of stresses in the vicinity of collapsed regions in heterogeneously ventilated lungs. We aimed to study the effects on ventilation and perfusion distributions of a ... -
A novel strategy to fit and validate physiological models: a case study of acardiorespiratory model for simulation of incremental aerobic exercise
(2023-03-01)
Article
Open AccessApplying complex mathematical models of physiological systems is challenging due to the large number of parameters. Identifying these parameters through experimentation is difficult, and although procedures for fitting and ... -
Serum neurofilament light chain levels predict long-term disability progression in patients with progressive multiple sclerosis
(2022-01-01)
Article
Open AccessObjective : There is a lack of sensitive and specific biomarkers for use in progressive multiple sclerosis (MS). The study aimed to assess the potential of serum neurofilament light chain (sNfL) levels as biomarker of ...