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dc.contributor.authorJulio Morán, Gemma
dc.contributor.authorLluch Margarit, Sara
dc.contributor.authorPujol Vives, Pere
dc.contributor.authorMerindano Encina, M. Dolores
dc.contributor.authorMarqués Calvo, M. Soledad
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Òptica i Optometria
dc.date.accessioned2015-11-23T12:33:16Z
dc.date.available2015-11-23T12:33:16Z
dc.date.issued2015-07-01
dc.identifier.citationJulio, G., Lluch, S., Pujol, P., Merindano, M., Marques, M.S. Conjunctival Short-term Evolution after Pterygium Excision. "Optometry and vision science", 01 Juliol 2015, vol. 92, núm. 7, p. 790-795.
dc.identifier.issn1040-5488
dc.identifier.urihttp://hdl.handle.net/2117/79559
dc.description.abstractPurpose To analyze conjunctival cytological features 1 month after pterygium excision using limbo-conjunctival autograft (LCA) with and without intraoperative mitomycin C and to assess tissue short-term evolution in both situations.; Methods Fifty-nine primary nasal pterygia from 59 patients were excised with LCA. Twenty-nine were treated with intraoperative mitomycin C 0.02% (MMC+) and 30 were treated without it (MMC-). Impression cytology was performed in nasal and temporal conjunctiva before and 1 month after the excision. Goblet cell density (GCD) and nucleus-to-cytoplasm nongoblet epithelial cell ratio were quantified.; Results Surgical strategy comparisons (intergroup comparisons): All the preoperative data were, in mean, within the reference range, except for a slight goblet cell hyperplasia in the area of the lesion in MMC+ but no significant differences were found between the groups (p = 0.079 for GCD and p = 0.245 for nucleus-to-cytoplasm ratio; analysis of variance). Clinically relevant differences after surgery were only shown in nasal GCD that was significantly lower in MMC+ than in MMC- (p = 0.000; analysis of variance), with the mean value in MMC+ slightly below normal values whereas that in MMC- remained normal. Tissue evolution (intragroup comparisons): No clinically relevant changes were found in MMC-. Data from MMC+ displayed no changes 1 month after surgery, except for nasal GCD that showed a significant reduction (p = 0.000; paired t test). Nevertheless, this GCD decrease was more modest than that previously described using mitomycin C without autograft, because in the present study, nasal GCD was not lower but similar to postoperative temporal data of the same eye (p = 0.164; paired t test).; Conclusions Limbo-conjunctival autograft is a good technique for conjunctiva early recovery. When mitomycin C was added, the GCD reduction was lower than described using other surgical techniques. Mitomycin C, in optimal concentration and exposure, associated with LCA could be a good clinical option to minimize pterygium recurrence.
dc.format.extent6 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Ciències de la visió
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina::Oftalmologia
dc.subject.lcshPterygium
dc.subject.lcshConjunctiva
dc.subject.lcshExcision (Surgery)
dc.subject.lcshExfoliative cytology
dc.subject.lcshMitomycin C
dc.subject.lcshEye--Cytology
dc.subject.otherpterygium
dc.subject.otherimpression cytology
dc.subject.othermitomycin C
dc.subject.otherlimbo-conjunctival autograft
dc.subject.othergoblet cells
dc.subject.otherMITOMYCIN-C APPLICATION
dc.subject.otherOCULAR SURFACE DISEASE
dc.subject.otherGOBLET CELL-DENSITY
dc.subject.otherIMPRESSION CYTOLOGY
dc.subject.otherLIMBAL-CONJUNCTIVAL
dc.subject.otherSURGERY
dc.subject.otherAUTOGRAFT
dc.subject.otherCORNEAL
dc.subject.otherRECURRENCE
dc.subject.otherTRIAL
dc.titleConjunctival Short-term Evolution after Pterygium Excision
dc.typeArticle
dc.subject.lemacUlls -- Citologia
dc.subject.lemacConjuntivitis
dc.subject.lemacCitologia
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1097/OPX.0000000000000622
dc.rights.accessOpen Access
drac.iddocument16670867
dc.description.versionPostprint (author's final draft)
upcommons.citation.authorJulio, G.; Lluch, S.; Pujol, P.; Merindano, M.; Marques, M.S.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameOptometry and vision science
upcommons.citation.volume92
upcommons.citation.number7
upcommons.citation.startingPage790
upcommons.citation.endingPage795


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