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Conjunctival Short-term Evolution after Pterygium Excision
dc.contributor.author | Julio Morán, Gemma |
dc.contributor.author | Lluch Margarit, Sara |
dc.contributor.author | Pujol Vives, Pere |
dc.contributor.author | Merindano Encina, M. Dolores |
dc.contributor.author | Marqués Calvo, M. Soledad |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria |
dc.date.accessioned | 2015-11-23T12:33:16Z |
dc.date.available | 2015-11-23T12:33:16Z |
dc.date.issued | 2015-07-01 |
dc.identifier.citation | Julio, G., Lluch, S., Pujol, P., Merindano, M., Marques, M.S. Conjunctival Short-term Evolution after Pterygium Excision. "Optometry and vision science", 01 Juliol 2015, vol. 92, núm. 7, p. 790-795. |
dc.identifier.issn | 1040-5488 |
dc.identifier.uri | http://hdl.handle.net/2117/79559 |
dc.description.abstract | Purpose To analyze conjunctival cytological features 1 month after pterygium excision using limbo-conjunctival autograft (LCA) with and without intraoperative mitomycin C and to assess tissue short-term evolution in both situations.; Methods Fifty-nine primary nasal pterygia from 59 patients were excised with LCA. Twenty-nine were treated with intraoperative mitomycin C 0.02% (MMC+) and 30 were treated without it (MMC-). Impression cytology was performed in nasal and temporal conjunctiva before and 1 month after the excision. Goblet cell density (GCD) and nucleus-to-cytoplasm nongoblet epithelial cell ratio were quantified.; Results Surgical strategy comparisons (intergroup comparisons): All the preoperative data were, in mean, within the reference range, except for a slight goblet cell hyperplasia in the area of the lesion in MMC+ but no significant differences were found between the groups (p = 0.079 for GCD and p = 0.245 for nucleus-to-cytoplasm ratio; analysis of variance). Clinically relevant differences after surgery were only shown in nasal GCD that was significantly lower in MMC+ than in MMC- (p = 0.000; analysis of variance), with the mean value in MMC+ slightly below normal values whereas that in MMC- remained normal. Tissue evolution (intragroup comparisons): No clinically relevant changes were found in MMC-. Data from MMC+ displayed no changes 1 month after surgery, except for nasal GCD that showed a significant reduction (p = 0.000; paired t test). Nevertheless, this GCD decrease was more modest than that previously described using mitomycin C without autograft, because in the present study, nasal GCD was not lower but similar to postoperative temporal data of the same eye (p = 0.164; paired t test).; Conclusions Limbo-conjunctival autograft is a good technique for conjunctiva early recovery. When mitomycin C was added, the GCD reduction was lower than described using other surgical techniques. Mitomycin C, in optimal concentration and exposure, associated with LCA could be a good clinical option to minimize pterygium recurrence. |
dc.format.extent | 6 p. |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Ciències de la visió |
dc.subject | Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Oftalmologia |
dc.subject.lcsh | Pterygium |
dc.subject.lcsh | Conjunctiva |
dc.subject.lcsh | Excision (Surgery) |
dc.subject.lcsh | Exfoliative cytology |
dc.subject.lcsh | Mitomycin C |
dc.subject.lcsh | Eye--Cytology |
dc.subject.other | pterygium |
dc.subject.other | impression cytology |
dc.subject.other | mitomycin C |
dc.subject.other | limbo-conjunctival autograft |
dc.subject.other | goblet cells |
dc.subject.other | MITOMYCIN-C APPLICATION |
dc.subject.other | OCULAR SURFACE DISEASE |
dc.subject.other | GOBLET CELL-DENSITY |
dc.subject.other | IMPRESSION CYTOLOGY |
dc.subject.other | LIMBAL-CONJUNCTIVAL |
dc.subject.other | SURGERY |
dc.subject.other | AUTOGRAFT |
dc.subject.other | CORNEAL |
dc.subject.other | RECURRENCE |
dc.subject.other | TRIAL |
dc.title | Conjunctival Short-term Evolution after Pterygium Excision |
dc.type | Article |
dc.subject.lemac | Ulls -- Citologia |
dc.subject.lemac | Conjuntivitis |
dc.subject.lemac | Citologia |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.1097/OPX.0000000000000622 |
dc.rights.access | Open Access |
local.identifier.drac | 16670867 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Julio, G.; Lluch, S.; Pujol, P.; Merindano, M.; Marques, M.S. |
local.citation.publicationName | Optometry and vision science |
local.citation.volume | 92 |
local.citation.number | 7 |
local.citation.startingPage | 790 |
local.citation.endingPage | 795 |
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