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Intestinal gas content and distribution in health and in patients with functional gut symptoms

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10.1111/nmo.12618
 
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hdl:2117/79538

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Bendezú, Álvaro
Barba, Elisabeth
Burri, Emanuel
Cisternas, Daniel
Malagelada Prats, Carolina
Segui, Santi
Accarino Garaventa, Anna María
Quiroga, Sergi
Monclús Lahoya, EvaMés informacióMés informacióMés informació
Navazo Álvaro, IsabelMés informacióMés informació
Malagelada Benapres, Juan Ramon
Azpiroz Vidaur, Fernando
Document typeArticle
Defense date2015-09
Rights accessOpen Access
All rights reserved. This work is protected by the corresponding intellectual and industrial property rights. Without prejudice to any existing legal exemptions, reproduction, distribution, public communication or transformation of this work are prohibited without permission of the copyright holder
Abstract
Background: The precise relation of intestinal gas to symptoms, particularly abdominal bloating and distension remains incompletely elucidated. Our aim was to define the normal values of intestinal gas volume and distribution and to identify abnormalities in relation to functional-type symptoms. Methods:Abdominal computed tomography scans were evaluated in healthy subjects (n = 37) and in patients in three conditions: basal (when they were feeling well; n = 88), during an episode of abdominal distension (n = 82) and after a challenge diet (n = 24). Intestinal gas content and distribution were measured by an original analysis program. Identification of patients outside the normal range was performed by machine learning techniques (one-class classifier). Results are expressed as median (IQR) or mean ± SE, as appropriate. Key Results: In healthy subjects the gut contained 95 (71, 141) mL gas distributed along the entire lumen. No differences were detected between patients studied under asymptomatic basal conditions and healthy subjects. However, either during a spontaneous bloating episode or once challenged with a flatulogenic diet, luminal gas was found to be increased and/or abnormally distributed in about one-fourth of the patients. These patients detected outside the normal range by the classifier exhibited a significantly greater number of abnormal features than those within the normal range (3.7 ± 0.4 vs 0.4 ± 0.1; p < 0.001). Conclusions & Inferences: The analysis of a large cohort of subjects using original techniques provides unique and heretofore unavailable information on the volume and distribution of intestinal gas in normal conditions and in relation to functional gastrointestinal symptoms.
CitationBendezú, Á., Barba, E., Burri, E., Cisternas, D., Malagelada, C., Segui, S., Accarino, A., Quiroga, S., Monclús, E., Navazo, I., Malagelada, J., Azpiroz, F. Intestinal gas content and distribution in health and in patients with functional gut symptoms. "Neurogastroenterology and motility", Setembre 2015, vol. 27, núm. 9, p. 1249-1257. 
URIhttp://hdl.handle.net/2117/79538
DOI10.1111/nmo.12618
ISSN1350-1925
Publisher versionhttp://onlinelibrary.wiley.com/doi/10.1111/nmo.12618/full
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