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dc.contributor.authorGouvêa de Barros, Bruno
dc.contributor.authorWeber dos Santos, Rodrigo
dc.contributor.authorLobosco, Marcelo
dc.contributor.authorAlonso Muñoz, Sergio
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.identifier.citationGouvêa, B., Weber, R., Lobosco, M., Alonso, S. Simulation of ectopic pacemakers in the heart: multiple ectopic beats generated by reentry inside fibrotic regions. "Biomed Research International", 17 Maig 2015, vol. 2015, p. 713058-1-713058-19.
dc.description.abstractThe inclusion of nonconducting media, mimicking cardiac fibrosis, in two models of cardiac tissue produces the formation of ectopic beats. The fraction of nonconducting media in comparison with the fraction of healthy myocytes and the topological distribution of cells determines the probability of ectopic beat generation. First, a detailed subcellular microscopic model that accounts for the microstructure of the cardiac tissue is constructed and employed for the numerical simulation of action potential propagation. Next, an equivalent discrete model is implemented, which permits a faster integration of the equations. This discrete model is a simplified version of the microscopic model that maintains the distribution of connections between cells. Both models produce similar results when describing action potential propagation in homogeneous tissue; however, they slightly differ in the generation of ectopic beats in heterogeneous tissue. Nevertheless, both models present the generation of reentry inside fibrotic tissues. This kind of reentry restricted to microfibrosis regions can result in the formation of ectopic pacemakers, that is, regions that will generate a series of ectopic stimulus at a fast pacing rate. In turn, such activity has been related to trigger fibrillation in the atria and in the ventricles in clinical and animal studies.
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica::Electrònica en cardiologia
dc.subject.lcshMedical electronics
dc.subject.lcshElectronics in cardiology
dc.subject.otherCardiac arrhythmia
dc.subject.otherEctopic beats
dc.subject.othercardiac modeling
dc.subject.othercomplex fractionated atrial electrograms
dc.titleSimulation of ectopic pacemakers in the heart: multiple ectopic beats generated by reentry inside fibrotic regions
dc.subject.lemacElectrònica mèdica
dc.subject.lemacElectrònica en cardiologia
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
dc.description.peerreviewedPeer Reviewed
dc.rights.accessOpen Access
dc.description.versionPostprint (published version)
local.citation.authorGouvêa, B.; Weber, R.; Lobosco, M.; Alonso, S.
local.citation.publicationNameBiomed Research International

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