Show simple item record

dc.contributor.authorLopez Gongora, Mariana
dc.contributor.authorEscartín, José Antonio
dc.contributor.authorMartinez Horta, Saul
dc.contributor.authorFernandez De Bobadilla, Ramon
dc.contributor.authorQuerol, Luis
dc.contributor.authorRomero Lafuente, Sergio
dc.contributor.authorMañanas Villanueva, Miguel Ángel
dc.contributor.authorRiba Serrano, Jordi
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.date.accessioned2015-10-23T16:05:41Z
dc.date.available2015-10-23T16:05:41Z
dc.date.issued2015-08-31
dc.identifier.citationLopez, M., Escartín, J.A., Martinez, S., Fernandez, R., Querol, L., Romero, S., Mañanas, M.A., Riba, J. Neurophysiological evidence of compensatory brain mechanisms in early-stage multiple sclerosis. "PLoS one", 31 Agost 2015, vol. 10, núm. 8.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/2117/78209
dc.description.abstractMultiple sclerosis (MS) is a chronic central nervous system disorder characterized by white matter inflammation, demyelination and neurodegeneration. Although cognitive dysfunction is a common manifestation, it may go unnoticed in recently-diagnosed patients. Prior studies suggest MS patients develop compensatory mechanisms potentially involving enhanced performance monitoring. Here we assessed the performance monitoring system in early-stage MS patients using the error-related negativity (ERN), an event-related brain potential (ERP) observed following behavioral errors. Twenty-seven early-stage MS patients and 31 controls were neuropsychologically assessed. Electroencephalography recordings were obtained while participants performed: a) a stop task and b) an auditory oddball task. Behavior and ERP measures were assessed. No differences in performance were found between groups in most neuropsychological tests or in behavior or ERP components in the auditory oddball task. However, the amplitude of the ERN associated with stop errors in the stop task was significantly higher in patients. ERN amplitude correlated positively with scores on the Expanded Disability Status Scale and the Multiple Sclerosis Severity Score, and negatively with the time since last relapse. Patients showed higher neuronal recruitment in tasks involving performance monitoring. Results suggest the development of compensatory brain mechanisms in early-stage MS and reflect the sensitivity of the ERN to detect these changes.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut
dc.subject.lcshMultiple sclerosis.
dc.subject.otherCLINICALLY ISOLATED SYNDROMES
dc.subject.otherEVENT-RELATED POTENTIALS
dc.subject.otherERROR-RELATED NEGATIVITY
dc.subject.otherCOGNITIVE DYSFUNCTION
dc.subject.otherATTENTION SYSTEM
dc.subject.otherMS PATIENTS
dc.subject.otherIMPAIRMENT
dc.subject.otherPERFORMANCE
dc.subject.otherACTIVATION
dc.subject.otherDISABILITY
dc.titleNeurophysiological evidence of compensatory brain mechanisms in early-stage multiple sclerosis
dc.typeArticle
dc.subject.lemacEsclerosi múltiple
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOART - BIOsignal Analysis for Rehabilitation and Therapy
dc.identifier.doi10.1371/journal.pone.0136786
dc.rights.accessOpen Access
local.identifier.drac16920716
dc.description.versionPostprint (published version)
local.citation.authorLopez, M.; Escartín, J.A.; Martinez, S.; Fernandez, R.; Querol, L.; Romero, S.; Mañanas, M.A.; Riba, J.
local.citation.publicationNamePLoS one
local.citation.volume10
local.citation.number8
dc.identifier.pmid26322632


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain