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dc.contributor.authorAlonso López, Joan Francesc
dc.contributor.authorRomero Lafuente, Sergio
dc.contributor.authorMañanas Villanueva, Miguel Ángel
dc.contributor.authorRiba Serrano, Jordi
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.date.accessioned2015-09-14T13:19:44Z
dc.date.available2015-09-14T13:19:44Z
dc.date.created2015-06-01
dc.date.issued2015-06-01
dc.identifier.citationAlonso, J.F., Romero, S., Mañanas, M.A., Riba, J. Serotonergic psychedelics temporarily modify information transfer in humans. "International journal of neuropsychopharmacology", 01 Juny 2015, núm. 8, p. 1-9.
dc.identifier.issn1461-1457
dc.identifier.urihttp://hdl.handle.net/2117/76775
dc.description.abstractBackground: Psychedelics induce intense modifications in the sensorium, the sense of "self," and the experience of reality. Despite advances in our understanding of the molecular and cellular level mechanisms of these drugs, knowledge of their actions on global brain dynamics is still incomplete. Recent imaging studies have found changes in functional coupling between frontal and parietal brain structures, suggesting a modification in information flow between brain regions during acute effects.; Methods: Here we assessed the psychedelic-induced changes in directionality of information flow during the acute effects of a psychedelic in humans. We measured modifications in connectivity of brain oscillations using transfer entropy, a nonlinear measure of directed functional connectivity based on information theory. Ten healthy male volunteers with prior experience with psychedelics participated in 2 experimental sessions. They received a placebo or a dose of ayahuasca, a psychedelic preparation containing the serotonergic 5-HT2A agonist N,N-dimethyltryptamine.; Results: The analysis showed significant changes in the coupling of brain oscillations between anterior and posterior recording sites. Transfer entropy analysis showed that frontal sources decreased their influence over central, parietal, and occipital sites. Conversely, sources in posterior locations increased their influence over signals measured at anterior locations. Exploratory correlations found that anterior-to-posterior transfer entropy decreases were correlated with the intensity of subjective effects, while the imbalance between anterior-to-posterior and posterior-to-anterior transfer entropy correlated with the degree of incapacitation experienced.; Conclusions: These results suggest that psychedelics induce a temporary disruption of neural hierarchies by reducing top-down control and increasing bottom-up information transfer in the human brain.
dc.format.extent9 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Enginyeria electrònica::Electrònica biomèdica
dc.subject.lcshHallucinogenic drugs
dc.subject.otherOscillatory brain dynamics
dc.subject.otherpsychedelics
dc.subject.otherfunctional connectivity
dc.subject.othertransfer entropy
dc.subject.otherhuman
dc.subject.otherPSYCHOACTIVE BEVERAGE AYAHUASCA
dc.subject.otherPOSITRON-EMISSION-TOMOGRAPHY
dc.subject.otherALPHA-RHYTHM
dc.subject.otherPSYCHOMETRIC ASSESSMENT
dc.subject.otherRATING-SCALE
dc.subject.otherEEG
dc.subject.otherPSILOCYBIN
dc.subject.otherPSYCHOSIS
dc.subject.otherFMRI
dc.titleSerotonergic psychedelics temporarily modify information transfer in humans
dc.typeArticle
dc.subject.lemacAl·lucinògens
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOART - BIOsignal Analysis for Rehabilitation and Therapy
dc.identifier.doi10.1093/ijnp/pyv039
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://ijnp.oxfordjournals.org/content/18/8/pyv039
dc.rights.accessOpen Access
local.identifier.drac16870391
dc.description.versionPostprint (published version)
local.citation.authorAlonso, J.F.; Romero, S.; Mañanas, M.A.; Riba, J.
local.citation.publicationNameInternational journal of neuropsychopharmacology
local.citation.volume18
local.citation.number8
local.citation.startingPage1
local.citation.endingPage9
dc.identifier.pmid25820842


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