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Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds
dc.contributor.author | Acosta Reyes, Francisco Javier |
dc.contributor.author | Subirana, Juan Antonio |
dc.contributor.author | Campos López, Josefina de Lourdes |
dc.contributor.author | Alechaga, Elida |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2015-09-07T08:12:22Z |
dc.date.available | 2015-09-07T08:12:22Z |
dc.date.created | 2015-03-17 |
dc.date.issued | 2015-03-17 |
dc.identifier.citation | Acosta, F.J., Subirana, J., Campos, J.Lourdes, Alechaga, E. Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds. "PLoS one", 17 Març 2015, núm. 3. |
dc.identifier.issn | 1932-6203 |
dc.identifier.uri | http://hdl.handle.net/2117/76646 |
dc.description.abstract | The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is favored in alternating AT sequences of DNA. Here we present new data for a different sequence, d(ATTAAT)(2), which is also found in the Hoogsteen conformation. Thus we demonstrate that other all-AT sequences of DNA with a different sequence may be found in the Hoogsteen conformation. We conclude that any all-AT sequence might acquire this conformation under appropriate conditions. We also compare the detailed features of DNA in either the Hoogsteen or Watson-Crick conformations. |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | DNA--Synthesis |
dc.subject.other | polymerase-iota |
dc.subject.other | base-pairs |
dc.subject.other | crystal |
dc.subject.other | complex |
dc.subject.other | replication |
dc.subject.other | refinement |
dc.subject.other | software |
dc.subject.other | refmac5 |
dc.title | Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds |
dc.type | Article |
dc.subject.lemac | ADN -- Estructura |
dc.contributor.group | Universitat Politècnica de Catalunya. MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques |
dc.identifier.doi | 10.1371/journal.pone.0120241 |
dc.relation.publisherversion | http://journals.plos.org/ |
dc.rights.access | Open Access |
local.identifier.drac | 15526251 |
dc.description.version | Postprint (published version) |
local.citation.author | Acosta, F.J.; Subirana, J.; Campos, J.Lourdes; Alechaga, E. |
local.citation.publicationName | PLoS one |
local.citation.volume | 10 |
local.citation.number | 3 |
local.citation.endingPage | 9 |
dc.identifier.pmid | 25781995 |
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