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dc.contributor.authorAcosta Reyes, Francisco Javier
dc.contributor.authorSubirana, Juan Antonio
dc.contributor.authorCampos López, Josefina de Lourdes
dc.contributor.authorAlechaga, Elida
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2015-09-07T08:12:22Z
dc.date.available2015-09-07T08:12:22Z
dc.date.created2015-03-17
dc.date.issued2015-03-17
dc.identifier.citationAcosta, F.J., Subirana, J., Campos, J.Lourdes, Alechaga, E. Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds. "PLoS one", 17 Març 2015, núm. 3.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/2117/76646
dc.description.abstractThe traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is favored in alternating AT sequences of DNA. Here we present new data for a different sequence, d(ATTAAT)(2), which is also found in the Hoogsteen conformation. Thus we demonstrate that other all-AT sequences of DNA with a different sequence may be found in the Hoogsteen conformation. We conclude that any all-AT sequence might acquire this conformation under appropriate conditions. We also compare the detailed features of DNA in either the Hoogsteen or Watson-Crick conformations.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshDNA--Synthesis
dc.subject.otherpolymerase-iota
dc.subject.otherbase-pairs
dc.subject.othercrystal
dc.subject.othercomplex
dc.subject.otherreplication
dc.subject.otherrefinement
dc.subject.othersoftware
dc.subject.otherrefmac5
dc.titleStructure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds
dc.typeArticle
dc.subject.lemacADN -- Estructura
dc.contributor.groupUniversitat Politècnica de Catalunya. MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques
dc.identifier.doi10.1371/journal.pone.0120241
dc.relation.publisherversionhttp://journals.plos.org/
dc.rights.accessOpen Access
local.identifier.drac15526251
dc.description.versionPostprint (published version)
local.citation.authorAcosta, F.J.; Subirana, J.; Campos, J.Lourdes; Alechaga, E.
local.citation.publicationNamePLoS one
local.citation.volume10
local.citation.number3
local.citation.endingPage9
dc.identifier.pmid25781995


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