Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds
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The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is favored in alternating AT sequences of DNA. Here we present new data for a different sequence, d(ATTAAT)(2), which is also found in the Hoogsteen conformation. Thus we demonstrate that other all-AT sequences of DNA with a different sequence may be found in the Hoogsteen conformation. We conclude that any all-AT sequence might acquire this conformation under appropriate conditions. We also compare the detailed features of DNA in either the Hoogsteen or Watson-Crick conformations.
CitationAcosta, F.J., Subirana, J., Campos, J.Lourdes, Alechaga, E. Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds. "PLoS one", 17 Març 2015, núm. 3.