Ir al contenido (pulsa Retorno)

Universitat Politècnica de Catalunya

    • Català
    • Castellano
    • English
    • LoginRegisterLog in (no UPC users)
  • mailContact Us
  • world English 
    • Català
    • Castellano
    • English
  • userLogin   
      LoginRegisterLog in (no UPC users)

UPCommons. Global access to UPC knowledge

Banner header
69.361 UPC E-Prints
You are here:
View Item 
  •   DSpace Home
  • E-prints
  • Grups de recerca
  • GNOM - Grup d'Optimització Numèrica i Modelització
  • Articles de revista
  • View Item
  •   DSpace Home
  • E-prints
  • Grups de recerca
  • GNOM - Grup d'Optimització Numèrica i Modelització
  • Articles de revista
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Boosting the chances to improve stroke treatment

Thumbnail
View/Open
stroke.pdf (262,1Kb)
 
10.1161/STROKEAHA.109.567404
 
  View UPCommons Usage Statistics
  LA Referencia / Recolecta stats
Includes usage data since 2022
Cita com:
hdl:2117/7571

Show full item record
Cobo Valeri, ErikMés informacióMés informacióMés informació
Secades, Julio
Miras, Francesc
González, José Antonio
Saver, Jeffrey L.
Corchero García, CristinaMés informacióMés informació
Rius Carrasco, RoserMés informacióMés informacióMés informació
Dávalos, Antoni
Document typeArticle
Defense date2010-03
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Background and Purpose—There is a lack of agreement regarding measuring the effects of stroke treatment in clinical trials, which often relies on the dichotomized value of 1 outcome scale. Alternative analyses consist mainly of 2 strategies: use all the information from an ordinal scale and combine information from several outcome scales in a single estimate. Methods—We reanalyzed 3 outcome scales that assessed patient recovery (modified Rankin Scale, National Institutes of Health Stroke Scale, and Barthel Index). With data collected from the 1652 patients in the Citicoline pooling data analysis, we used 2 standard techniques of exploratory multivariate analysis to analyze the distances among ranks and to isolate the common and the unique information provided by each of the 3 scales. Results—The different scale values correspond to gradually different patient status, confirming that information is lost when a scale is collapsed to just 2 values, whether recovered or not. The scales shared 90.7% (95% CI, 84.5–96.9) of their information, with no individual scale contributing unique information. Conclusions—Salient stroke outcome information is lost when an ordinal scale is collapsed into fewer categories. In contrast, the full scales provide a comprehensive patient outcome estimate. Furthermore, in the context of stroke clinical trials, those scales are highly correlated, providing the rationale to pool them into a single estimate. These insights may be used to optimize the analysis of stroke trials to increase study power to detect efficacious interventions.
CitationCobo, E. [et al.]. Boosting the chances to improve stroke treatment. "Stroke", Març 2010, vol. 41, núm. 3, p. 143-150. 
URIhttp://hdl.handle.net/2117/7571
DOI10.1161/STROKEAHA.109.567404
ISSN0039-2499
Collections
  • GNOM - Grup d'Optimització Numèrica i Modelització - Articles de revista [107]
  • LIAM - Laboratori de Modelització i Anàlisi de la Informació - Articles de revista [50]
  • GREMA - Grup de Recerca en Estadística Matemàtica i les seves Aplicacions - Articles de revista [51]
  • Departament d'Estadística i Investigació Operativa - Articles de revista [798]
  View UPCommons Usage Statistics

Show full item record

FilesDescriptionSizeFormatView
stroke.pdf262,1KbPDFView/Open

Browse

This CollectionBy Issue DateAuthorsOther contributionsTitlesSubjectsThis repositoryCommunities & CollectionsBy Issue DateAuthorsOther contributionsTitlesSubjects

© UPC Obrir en finestra nova . Servei de Biblioteques, Publicacions i Arxius

info.biblioteques@upc.edu

  • About This Repository
  • Metadata under:Metadata under CC0
  • Contact Us
  • Send Feedback
  • Privacy Settings
  • Inici de la pàgina