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dc.contributor.authorGaya, Anna
dc.contributor.authorGranell, Miquel
dc.contributor.authorUrbano-Ispiuza, Álvaro
dc.contributor.authorPons, Aina
dc.contributor.authorAróstigui, Juan Ignacio
dc.contributor.authorGel Moreno, Bernat
dc.contributor.authorNavarro, Alfons
dc.contributor.authorJansana, Sonia
dc.contributor.authorArtells, Rosa
dc.contributor.authorMonzó, Mariano
dc.contributor.authorMontserrat, Emili
dc.contributor.authorYagüe, Jordi
dc.contributor.authorJuan, Manel
dc.contributor.authorRozman, Ciril
dc.contributor.authorCarreras, Enric
dc.contributor.authorRovira, Montserrat
dc.contributor.authorMartínez, Carmen
dc.contributor.authorFernández-Avilés, Francesc
dc.contributor.authorTalarn, Carme
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Llenguatges i Sistemes Informàtics
dc.identifier.citationGranell, M. [et al.]. Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation. "Blood", 04 Setembre 2008.
dc.description.abstractThe inflammasomes are macromolecular cytosolic complexes involved in the production of interleukin-1beta (IL-1beta) and IL-18 in response to several pathogen-derived stimuli. Such interleukins have been implicated in the origin of severe allogeneic stem cell transplant (allo-SCT) complications. We analyzed the relationship between the interindividual variability in inflammasome protein-encoding genes in donors and patients and clinical outcome after allo-SCT. Fourteen common genetic variants in 5 genes of the inflammasome, namely, NLRP1, NLRP2, NLRP3, CARD8, and CASP5, were genotyped in 133 human leukocyte antigen-identical sibling pairs undergoing allo-SCT. In the multivariate analysis, donor variants in NLRP2 and NLRP3 were the most important prognostic factors for the clinical outcome after allo-SCT. Thus, donor TT genotype at rs10925027 in NLRP3 was associated with disease relapse (odds ratio (OR) = 6.3, P = 1 x 10(-7)), and donor GG genotype at rs1043684 in NLRP2 was associated with nonrelapse mortality (OR = 4.4, P = 6 x 10(-4)) and overall survival (OR = 3.1, P = .001). In addition, patient AA genotype at rs5862 in NLRP1 was associated with nonrelapse mortality (OR = 2.8, P = .005) and overall survival (OR = 2.0, P = .009). These results suggest that inflammasome genetic variants are important prognostic factors for the outcome of allo-SCT. If validated in larger studies, including unrelated allo-SCT, NLRPs genotype would become an important factor in donor selection.
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina::Medicina interna
dc.subject.lcshHematological oncology
dc.titleCommon variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation
dc.subject.lemacCàncer -- Investigació
dc.contributor.groupUniversitat Politècnica de Catalunya. ALBCOM - Algorismia, Bioinformàtica, Complexitat i Mètodes Formals
dc.description.peerreviewedPeer Reviewed
dc.rights.accessRestricted access - publisher's policy
dc.description.versionPostprint (published version)
local.citation.authorGranell, M.; Urbano-Ispiuza, Á.; Pons, A.; Aróstigui, J.; Gel, B.; Navarro, A.; Jansana, S.; Artells, R.; Gaya, A.; Talarn, C.; Fernández-Avilés, F.; Martínez, C.; Rovira, M.; Carreras, E.; Rozman, C.; Juan, M.; Yagüe, J.; Montserrat, E.; Monzó, M.

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