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dc.contributor.authorMazo Barbara, Laura del
dc.contributor.authorJohansson, Linh Ha Huong Lovisa
dc.contributor.authorTampieri, Francesco
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Ciència i Enginyeria dels Materials
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials
dc.date.accessioned2024-03-18T15:53:52Z
dc.date.available2024-03-18T15:53:52Z
dc.date.issued2024-02
dc.identifier.citationDel Mazo, L. [et al.]. Toughening 3D printed biomimetic hydroxyapatite scaffolds: polycaprolactone-based self-hardening inks. "Acta biomaterialia", Febrer 2024, vol. 177, p. 506-524.
dc.identifier.issn1878-7568
dc.identifier.urihttp://hdl.handle.net/2117/404879
dc.description.abstractThe application of 3D printing to calcium phosphates has opened unprecedented possibilities for the fabrication of personalized bone grafts. However, their biocompatibility and bioactivity are counterbalanced by their high brittleness. In this work we aim at overcoming this problem by developing a self-hardening ink containing reactive ceramic particles in a polycaprolactone solution instead of the traditional approach that use hydrogels as binders. The presence of polycaprolactone preserved the printability of the ink and was compatible with the hydrolysis-based hardening process, despite the absence of water in the ink and its hydrophobicity. The microstructure evolved from a continuous polymeric phase with loose ceramic particles to a continuous network of hydroxyapatite nanocrystals intertwined with the polymer, in a configuration radically different from the polymer/ceramic composites obtained by fused deposition modelling. This resulted in the evolution from a ductile behavior, dominated by the polymer, to a stiffer behavior as the ceramic phase reacted. The polycaprolactone binder provides two highly relevant benefits compared to hydrogel-based inks. First, the handleability and elasticity of the as-printed scaffolds, together with the proven possibility of eliminating the solvent, opens the door to implanting the scaffolds freshly printed once lyophilized, while in a ductile state, and the hardening process to take place inside the body, as in the case of calcium phosphate cements. Second, even with a hydroxyapatite content of more than 92%, the flexural strength and toughness of the scaffolds after hardening are twice and five times those of the all-ceramic scaffolds obtained with the hydrogel-based inks, respectively.
dc.format.extent19 p.
dc.language.isoeng
dc.publisherElsevier
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica
dc.subject.lcshHydroxyapatite
dc.subject.lcshTissue engineering
dc.subject.lcshCalcium phosphate
dc.subject.otherHydroxyapatite
dc.subject.otherBone scaffolds
dc.subject.otherPolycaprolactone
dc.subject.otherMechanical properties
dc.subject.other3D Printing
dc.titleToughening 3D printed biomimetic hydroxyapatite scaffolds: polycaprolactone-based self-hardening inks
dc.typeArticle
dc.subject.lemacHidroxiapatita
dc.subject.lemacEnginyeria de teixits
dc.subject.lemacFosfat de calci
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1016/j.actbio.2024.02.012
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1742706124000710
dc.rights.accessOpen Access
local.identifier.drac37970572
dc.description.versionPostprint (published version)
dc.contributor.covenanteeInstitut de Recerca Sant Joan de Déu
dc.contributor.covenanteeMimetis Biomaterials
dc.contributor.covenanteeCentro de Investigación Biomédica en Red. Bioingeniería, Biomateriales y Nanomedicina
dc.contributor.covenanteeInstitut de Bioenginyeria de Catalunya
local.citation.authorDel Mazo, L.; Johansson, L.; Tampieri, F.; Ginebra, M.P.
local.citation.publicationNameActa biomaterialia
local.citation.volume177
local.citation.startingPage506
local.citation.endingPage524


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