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dc.contributor.authorWhisler, Jordan
dc.contributor.authorShahreza, Somayeh
dc.contributor.authorSchlegelmilch, Karin
dc.contributor.authorEge, Nil
dc.contributor.authorJavanmardi, Yousef
dc.contributor.authorMalandrino, Andrea
dc.contributor.authorAgrawal, Ayushi
dc.contributor.authorFantin, Alessandro
dc.contributor.authorSerwinski, Bianca
dc.contributor.authorAzizgolshani, Hesham
dc.contributor.authorPark, Clara
dc.contributor.authorShone, Victoria
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials
dc.date.accessioned2023-11-02T13:54:05Z
dc.date.available2023-11-02T13:54:05Z
dc.date.issued2023-08-11
dc.identifier.citationWhisler, J. [et al.]. Emergent mechanical control of vascular morphogenesis. "Science advances", 11 Agost 2023, vol. 9, núm. 32.
dc.identifier.issn2375-2548
dc.identifier.urihttp://hdl.handle.net/2117/395703
dc.description.abstractVascularization is driven by morphogen signals and mechanical cues that coordinately regulate cellular force generation, migration, and shape change to sculpt the developing vascular network. However, it remains unclear whether developing vasculature actively regulates its own mechanical properties to achieve effective vascularization. We engineered tissue constructs containing endothelial cells and fibroblasts to investigate the mechanics of vascularization. Tissue stiffness increases during vascular morphogenesis resulting from emergent interactions between endothelial cells, fibroblasts, and ECM and correlates with enhanced vascular function. Contractile cellular forces are key to emergent tissue stiffening and synergize with ECM mechanical properties to modulate the mechanics of vascularization. Emergent tissue stiffening and vascular function rely on mechanotransduction signaling within fibroblasts, mediated by YAP1. Mouse embryos lacking YAP1 in fibroblasts exhibit both reduced tissue stiffness and develop lethal vascular defects. Translating our findings through biology-inspired vascular tissue engineering approaches will have substantial implications in regenerative medicine.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica
dc.subject.lcshMorphogenesis
dc.titleEmergent mechanical control of vascular morphogenesis
dc.typeArticle
dc.subject.lemacMorfogènesi
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1126/sciadv.adg9781
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.science.org/doi/10.1126/sciadv.adg9781
dc.rights.accessOpen Access
local.identifier.drac37016383
dc.description.versionPostprint (published version)
local.citation.authorWhisler, J.; Shahreza, S.; Schlegelmilch, K.; Ege, N.; Javanmardi, Y.; Malandrino, A.; Agrawal, A.; Fantin, A.; Serwinski, B.; Azizgolshani, H.; Park, C.; Shone, V.
local.citation.publicationNameScience advances
local.citation.volume9
local.citation.number32


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