Transcranial, noninvasive evaluation of the potential misery perfusion during hyperventilation therapy of traumatic brain injury patients
Cita com:
hdl:2117/387157
Document typeArticle
Defense date2023-04-26
Rights accessOpen Access
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Abstract
Hyperventilation (HV) therapy uses vasoconstriction to reduce intracranial pressure (ICP) by reducing cerebral blood volume. However, as HV also lowers cerebral blood flow (CBF), it may provoke misery perfusion (MP) where the decrease in CBF is coupled with increased oxygen extraction fraction (OEF). MP may rapidly lead to the exhaustion of brain energy metabolites, making it vulnerable to ischemia. MP is difficult to detect at the bedside, which is where transcranial hybrid, near-infrared spectroscopies are promising since they noninvasively measure OEF and CBF.
CitationTagliabue, S. [et al.]. Transcranial, noninvasive evaluation of the potential misery perfusion during hyperventilation therapy of traumatic brain injury patients. "Journal of neurotrauma", 26 Abril 2023,
ISSN0897-7151
Publisher versionhttps://www.liebertpub.com/doi/abs/10.1089/neu.2022.0419
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