Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo
Cita com:
hdl:2117/384289
CovenanteeInstitut de Recerca Sant Joan de Déu; Mimetis Biomaterials; Universitat Autònoma de Barcelona; Institut de Bioenginyeria de Catalunya
Document typeArticle
Defense date2022-01-01
PublisherWiley (John Wiley & Sons)
Rights accessOpen Access
Except where otherwise noted, content on this work
is licensed under a Creative Commons license
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Attribution-NonCommercial-NoDerivs 4.0 International
Abstract
Plasma-treated hydrogels have been put forward as a potential selective osteosarcoma therapy through the release of reactive species to the diseased site. To allow their translation to the clinics, it is crucial to show that the oxidative stress delivered by such hydrogels does not adversely affect healthy tissues. This is evaluated here by investigating the in vivo performance of a robocasted calcium phosphate cement infiltrated by a plasma-treated hydrogel. The plasma-treated composite implanted in a critical size bone defect of healthy rabbits revealed its safety, allowing equivalent bone ingrowth compared to the control scaffolds and to that of direct plasma treatment of the bone defect. This opens the door for using composite biomaterials containing plasma-generated reactive species in bone therapies.
CitationSole, X. [et al.]. Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo. "Plasma processes and polymers", 1 Gener 2022, vol. 20, núm. e2200155, p. 1-19.
ISSN1612-8869
Publisher versionhttps://onlinelibrary.wiley.com/doi/10.1002/ppap.202200155
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- BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits - Articles de revista [456]
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