Degenerate time-dependent network dynamics anticipate seizures in human epileptic brain
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10.1371/journal.pbio.2002580
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/380572
Tipus de documentArticle
Data publicació2018-04-05
EditorPublic Library of Science (PLOS)
Condicions d'accésAccés obert
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continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
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Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional
Abstract
Epileptic seizures are known to follow specific changes in brain dynamics. While some algorithms can nowadays robustly detect these changes, a clear understanding of the mechanism bywhich these alterations occur and generate seizures is still lacking. Here, we provide crossvalidated evidence that such changes are initiated by an alteration of physiological network state dynamics. Specifically, our analysis of long intracranial electroencephalography (iEEG) recordings from a group of 10 patients identifies a critical phase of a few hours in which time-dependent network states become less variable ("degenerate"), and this phase is followed by a global functional connectivity reduction before seizure onset. This critical phase is characterized by an abnormal occurrence of highly correlated network instances and is shown to be particularly associated with the activity of the resected regions in patients with validated postsurgical outcome. Our approach characterizes preseizure network dynamics as acascade of2sequential events providing new insights into seizure prediction and control.
CitacióTauste Campo, A. [et al.]. Degenerate time-dependent network dynamics anticipate seizures in human epileptic brain. "PLoS biology", 5 Abril 2018, vol. 16, núm. 4, p. 1-31.
ISSN1545-7885
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