3D printing with star-shaped strands: a new approach to enhance in vivo bone regeneration
Visualitza/Obre
10.1016/j.bioadv.2022.212807
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/370830
Realitzat a/ambMimetis Biomaterials; Institut de Recerca Sant Joan de Déu; Universidade de Vigo; Universitat de Barcelona; Universitat Autònoma de Barcelona; Institut de Bioenginyeria de Catalunya
Tipus de documentArticle
Data publicació2022-06-01
EditorElsevier
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
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Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional
Abstract
Concave surfaces have shown to promote bone regeneration in vivo. However, bone scaffolds obtained by direct ink writing, one of the most promising approaches for the fabrication of personalized bone grafts, consist mostly of convex surfaces, since they are obtained by microextrusion of cylindrical strands. By modifying the geometry of the nozzle, it is possible to print 3D structures composed of non-cylindrical strands and favor the presence of concave surfaces. In this work, we compare the in vivo performance of 3D-printed calcium phosphate scaffolds with either conventional cylindrical strands or star-shaped strands, in a rabbit femoral condyle model. Monocortical defects, drilled in contralateral positions, are randomly grafted with the two scaffold configurations, with identical composition. The samples are explanted eight weeks post-surgery and assessed by µ-CT and resin-embedded histological observations. The results reveal that the scaffolds containing star-shaped strands have better osteoconductive properties, guiding the newly formed bone faster towards the core of the scaffolds, and enhance bone regeneration, although the increase is not statistically significant (p > 0.05). This new approach represents a turning point towards the optimization of pore shape in 3D-printed bone grafts, further boosting the possibilities that direct ink writing technology offers for patient-specific applications.
CitacióRaymond, S. [et al.]. 3D printing with star-shaped strands: a new approach to enhance in vivo bone regeneration. "Biomaterials advances", 1 Juny 2022, vol. 137, núm. 212807, p. 1-11.
ISSN2772-9508
Versió de l'editorhttps://www.sciencedirect.com/science/article/pii/S277295082200084X
Col·leccions
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- Departament de Ciència i Enginyeria de Materials - Articles de revista [734]
- BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits - Articles de revista [439]
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