Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
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hdl:2117/370565
Tipus de documentArticle
Data publicació2022-06-09
EditorRoyal Society of Chemistry (RSC)
Condicions d'accésAccés obert
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Reconeixement-NoComercial 4.0 Internacional
ProjecteAPACHE - Atmospheric Pressure plAsma meets biomaterials for bone Cancer HEaling (EC-H2020-714793)
Abstract
Hydrogels have been recently proposed as suitable materials to generate reactive oxygen and nitrogen species (RONS) upon gas-plasma treatment, and postulated as promising alternatives to conventional cancer therapies. Acting as delivery vehicles that allow a controlled release of RONS to the diseased site, plasma-treated hydrogels can overcome some of the limitations presented by plasma-treated liquids in in vivo therapies. In this work, we optimized the composition of a methylcellulose (MC) hydrogel to confer it with the ability to form a gel at physiological temperatures while remaining in the liquid phase at room temperature to allow gas-plasma treatment with suitable formation of plasma-generated RONS. MC hydrogels demonstrated the capacity for generation, prolonged storage and release of RONS. This release induced cytotoxic effects on the osteosarcoma cancer cell line MG-63, reducing its cell viability in a dose-response manner. These promising results postulate plasma-treated thermosensitive hydrogels as good candidates to provide local anticancer therapies.
CitacióSole, X. [et al.]. Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose. "Biomaterials science", 9 Juny 2022, vol. 10, núm. 14, p. 3845-3855.
ISSN2047-4830
Versió de l'editorhttps://pubs.rsc.org/en/content/articlelanding/2022/BM/D2BM00308B
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