Genetic, parental and lifestyle factors influence telomere length
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hdl:2117/369489
Tipus de documentArticle
Data publicació2022
EditorNature Research
Condicions d'accésAccés obert
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Reconeixement 4.0 Internacional
Abstract
The average length of telomere repeats (TL) declines with age and is considered to be a marker of biological ageing. Here, we measured TL in six blood cell types from 1046 individuals using the clinically validated Flow-FISH method. We identified remarkable cell-type-specific variations in TL. Host genetics, environmental, parental and intrinsic factors such as sex, parental age, and smoking are associated to variations in TL. By analysing the genome-wide methylation patterns, we identified that the association of maternal, but not paternal, age to TL is mediated by epigenetics. Single-cell RNA-sequencing data for 62 participants revealed differential gene expression in T-cells. Genes negatively associated with TL were enriched for pathways related to translation and nonsense-mediated decay. Altogether, this study addresses cell-type-specific differences in telomere biology and its relation to cell-type-specific gene expression and highlights how perinatal factors play a role in determining TL, on top of genetics and lifestyle.
CitacióAndreu Sánchez, S. [et al.]. Genetic, parental and lifestyle factors influence telomere length. "Communications Biology", 2022, vol. 5, 565.
ISSN2399-3642
Versió de l'editorhttps://www.nature.com/articles/s42003-022-03521-7
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s42003-022-03521-7.pdf | 2,493Mb | Visualitza/Obre |