Relationship between sleep stages and HRV response in obstructive sleep apnea patients
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10.1109/EMBC46164.2021.9630148
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/366181
Tipus de documentText en actes de congrés
Data publicació2021
EditorInstitute of Electrical and Electronics Engineers (IEEE)
Condicions d'accésAccés obert
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Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Patients suffering from obstructive sleep apnea (OSA) usually present an increased sympathetic activity caused by the intermittent hypoxia effect on autonomic control. This study evaluated the relationship between sleep stages and the apnea duration, frequency, and type, as well as their impact on HRV markers in different groups of disease severity. The hypnogram and R-R interval signals were extracted in 81 OSA patients from night polysomnographic (PSG) recordings. The apnea-hypopnea index (AHI) defined patient classification as mild-moderate (AHI<=30, n=44) or severe (AHI>30, n=37). The normalized power in VLH, LF, and HF bands of RR series were estimated by a time-frequency approach and averaged in 1-min epochs of normal and apnea segments. The autonomic response and the impact of sleep stages were assessed in both segments to compare patient groups. Deeper sleep stages (particularly S2) concentrated the shorter and mild apnea episodes (from 10 to 40 s) compared to light (SWS) and REM sleep. Longer episodes (>50 s) although less frequent, were of similar incidence in all stages. This pattern was more pronounced for the group of severe patients. Moreover, during apnea segments, LF nu was higher (p=0.044) for the severe group, since V LF nu and HF nu presented the greatest changes when compared to normal segments. The non-REM sleep seems to better differentiate OSA patients groups, particularly through VLF nu and HF nu (p<0.001). A significant difference in both sympathetic and vagal modulation between REM and non-REM sleep was only found within the severe group. These results confirm the importance of considering sleep stages for HRV analysis to further assess OSA disease severity, beyond the traditional and clinically limited AHI values.Clinical relevance—Accounting for sleep stages during HRV analysis could better assess disease severity in OSA patients.
CitacióRomero, D.; Jane, R. Relationship between sleep stages and HRV response in obstructive sleep apnea patients. A: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. "2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)". Institute of Electrical and Electronics Engineers (IEEE), 2021, p. 5535-5538. ISBN 978-1-7281-1179-7. DOI 10.1109/EMBC46164.2021.9630148.
ISBN978-1-7281-1179-7
Versió de l'editorIEEE
Altres identificadorshttps://ieeexplore.ieee.org/document/9630148
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EMBC2021 vF.pdf | Preprint de la versió final | 73,59Kb | Visualitza/Obre |