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dc.contributor.authorHoyo Pérez, Javier
dc.contributor.authorBassegoda Puigdomenech, Arnau
dc.contributor.authorTzanov, Tzanko
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2022-03-07T12:11:19Z
dc.date.available2023-02-22T01:27:34Z
dc.date.issued2022-07
dc.identifier.citationHoyo, J.; Bassegoda, A.; Tzanov, T. Electrochemical quantification of biomarker myeloperoxidase. "Zeitschrift für Naturforschung. Section C, a journal of biosciences", juliol 2022, vol. 77, num. 7-8, p. 297-302.
dc.identifier.issn0939-5075
dc.identifier.urihttp://hdl.handle.net/2117/363520
dc.description.abstractPoint of care testing (PoCT) devices permit precise and rapid detection of disease-related biomarkers contributing to an early disease diagnosis and administration of an appropriate treatment. The enzyme myeloperoxidase (MPO) is a relevant biomarker for infection and inflammation events assessment; however its direct electrochemical quantification is hindered by the limited accessibility to the iron atom in its active center. Herein, such hindrance of the MPO biomolecule is overcome using the redox mediator 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS). The charge involved in the electrochemical reduction of the MPO-oxidized ABTS is correlated with the concentration of MPO. The use of ABTS allowed for the electrochemical assessment of a wide range of MPO concentrations (10–1000 nM) including those reported for wound infections, chronic obstructive pulmonary disease and early adverse cardiac events. The developed electroanalytical approach is rapid and inexpensive, and thus suitable for implementation in PoCT devices.
dc.format.extent22 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Enginyeria química::Química física::Electroquímica
dc.subject.lcshElectrochemistry
dc.subject.lcshBiochemical markers
dc.subject.otherABTS
dc.subject.otherDisease biomarker
dc.subject.otherElectrochemical detection
dc.subject.otherMyeloperoxidase
dc.titleElectrochemical quantification of biomarker myeloperoxidase
dc.typeArticle
dc.subject.lemacElectroquímica
dc.subject.lemacMarcadors bioquímics
dc.contributor.groupUniversitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.identifier.doi10.1515/znc-2021-0274
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.degruyter.com/document/doi/10.1515/znc-2021-0274/html
dc.rights.accessOpen Access
local.identifier.drac32820569
dc.description.versionPostprint (author's final draft)
dc.relation.projectidinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104111RB-I00/ES/RECUBRIMIENTOS DE HIDROGEL QUE CONTIENEN NANOPARTICULAS ANTIMICROBIANAS PARA COMBATIR INFECCIONES ASOCIADAS AL USO DE CATETERES POR BACTERIAS RESISTENTES A LOS ANTIBIOTICOS/
local.citation.authorHoyo, J.; Bassegoda, A.; Tzanov, T.
local.citation.publicationNameZeitschrift für Naturforschung. Section C, a journal of biosciences
local.citation.volume77
local.citation.number0
local.citation.number7-8
local.citation.startingPage297
local.citation.endingPage302


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