Mostra el registre d'ítem simple
Engineered microtissues for the bystander therapy against cancer
dc.contributor.author | Blanco Fernández, Bárbara |
dc.contributor.author | Cano Torres, Irene |
dc.contributor.author | Garrido, Cristina |
dc.contributor.author | Rubi Sans, Gerard |
dc.contributor.author | Sanchez Cid, Lourdes |
dc.contributor.author | Guerra Rebollo, Marta |
dc.contributor.author | Rubio, Nuria |
dc.contributor.author | Blanco, Jeronimo |
dc.contributor.author | Pérez Amodio, Soledad Graciela |
dc.contributor.author | Mateos Timoneda, Miguel Ángel |
dc.contributor.author | Engel López, Elisabeth |
dc.contributor.other | Universitat Politècnica de Catalunya. Doctorat en Enginyeria Biomèdica |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials |
dc.date.accessioned | 2022-02-11T08:36:30Z |
dc.date.available | 2023-02-01T01:27:12Z |
dc.date.issued | 2021-02-01 |
dc.identifier.citation | Blanco Fernández, B. [et al.]. Engineered microtissues for the bystander therapy against cancer. "Materials science & engineering. C, Biomimetic materials, sensors and systems", 1 Febrer 2021, vol. 121, p. 1111854:1-111854:13. |
dc.identifier.issn | 1873-0191 |
dc.identifier.uri | http://hdl.handle.net/2117/362135 |
dc.description.abstract | Thymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this strategy requires multiple TK-hAMSCs administrations and a substantial number of cells. Therefore, for clinical translation, it is necessary to find a biocompatible scaffold providing TK-hAMSCs retention in the implantation site against their rapid wash-out. We have developed a microtissue (MT) composed by TKhAMSCs and a scaffold made of polylactic acid microparticles and cell-derived extracellular matrix deposited by hAMSCs. The efficacy of these MTs as vehicles for TK-hAMSCs/GCV bystander therapy was evaluated in a rodent model of human prostate cancer. Subcutaneously implanted MTs were integrated in the surrounding tissue, allowing neovascularization and maintenance of TK-hAMSCs viability. Furthermore, MTs implanted beside tumors allowed TK-hAMSCs migration towards tumor cells and, after GCV administration, inhibited tumor growth. These results indicate that TK-hAMSCs-MTs are promising cell reservoirs for clinical use of therapeutic MSCs in bystander therapies. |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
dc.subject.lcsh | Stem cells |
dc.subject.lcsh | Cancer--Treatment |
dc.subject.lcsh | Bioluminescence |
dc.subject.lcsh | Tissue engineering |
dc.subject.other | Self-assembled cell-based microtissues |
dc.subject.other | Bystander therapy |
dc.subject.other | Adipose mesenchymal stem cells |
dc.subject.other | Cancer |
dc.subject.other | Bioluminescence |
dc.title | Engineered microtissues for the bystander therapy against cancer |
dc.type | Article |
dc.subject.lemac | Cèl·lules mare |
dc.subject.lemac | Càncer -- Tractament |
dc.subject.lemac | Bioluminescència |
dc.subject.lemac | Enginyeria de teixits |
dc.contributor.group | Universitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies |
dc.identifier.doi | 10.1016/j.msec.2020.111854 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/abs/pii/S0928493120337735 |
dc.rights.access | Open Access |
local.identifier.drac | 30796401 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Blanco Fernández, Bárbara; Cano, I.; Garrido, C.; Rubi-Sans, G.; Sanchez-Cid, L.; Guerra, M.; Rubio, N.; Blanco, J.; Perez, S.; Mateos, M.; Engel, E. |
local.citation.publicationName | Materials science & engineering. C, Biomimetic materials, sensors and systems |
local.citation.volume | 121 |
local.citation.startingPage | 1111854:1 |
local.citation.endingPage | 111854:13 |
Fitxers d'aquest items
Aquest ítem apareix a les col·leccions següents
-
Articles de revista [398]
-
Articles de revista [104]
-
Articles de revista [729]