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dc.contributor.authorBlanco Fernández, Bárbara
dc.contributor.authorCano Torres, Irene
dc.contributor.authorGarrido, Cristina
dc.contributor.authorRubi Sans, Gerard
dc.contributor.authorSanchez Cid, Lourdes
dc.contributor.authorGuerra Rebollo, Marta
dc.contributor.authorRubio, Nuria
dc.contributor.authorBlanco, Jeronimo
dc.contributor.authorPérez Amodio, Soledad Graciela
dc.contributor.authorMateos Timoneda, Miguel Ángel
dc.contributor.authorEngel López, Elisabeth
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Enginyeria Biomèdica
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials
dc.date.accessioned2022-02-11T08:36:30Z
dc.date.issued2021-02-01
dc.identifier.citationBlanco Fernández, B. [et al.]. Engineered microtissues for the bystander therapy against cancer. "Materials science & engineering. C, Biomimetic materials, sensors and systems", 1 Febrer 2021, vol. 121, p. 1111854:1-111854:13.
dc.identifier.issn1873-0191
dc.identifier.urihttp://hdl.handle.net/2117/362135
dc.description.abstractThymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this strategy requires multiple TK-hAMSCs administrations and a substantial number of cells. Therefore, for clinical translation, it is necessary to find a biocompatible scaffold providing TK-hAMSCs retention in the implantation site against their rapid wash-out. We have developed a microtissue (MT) composed by TKhAMSCs and a scaffold made of polylactic acid microparticles and cell-derived extracellular matrix deposited by hAMSCs. The efficacy of these MTs as vehicles for TK-hAMSCs/GCV bystander therapy was evaluated in a rodent model of human prostate cancer. Subcutaneously implanted MTs were integrated in the surrounding tissue, allowing neovascularization and maintenance of TK-hAMSCs viability. Furthermore, MTs implanted beside tumors allowed TK-hAMSCs migration towards tumor cells and, after GCV administration, inhibited tumor growth. These results indicate that TK-hAMSCs-MTs are promising cell reservoirs for clinical use of therapeutic MSCs in bystander therapies.
dc.language.isoeng
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
dc.subject.lcshStem cells
dc.subject.lcshCancer--Treatment
dc.subject.lcshBioluminescence
dc.subject.lcshTissue engineering
dc.subject.otherSelf-assembled cell-based microtissues
dc.subject.otherBystander therapy
dc.subject.otherAdipose mesenchymal stem cells
dc.subject.otherCancer
dc.subject.otherBioluminescence
dc.titleEngineered microtissues for the bystander therapy against cancer
dc.typeArticle
dc.subject.lemacCèl·lules mare
dc.subject.lemacCàncer -- Tractament
dc.subject.lemacBioluminescència
dc.subject.lemacEnginyeria de teixits
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
dc.identifier.doi10.1016/j.msec.2020.111854
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0928493120337735
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac30796401
dc.description.versionPostprint (author's final draft)
dc.date.lift2023-02
local.citation.authorBlanco Fernández, Bárbara; Cano, I.; Garrido, C.; Rubi-Sans, G.; Sanchez-Cid, L.; Guerra, M.; Rubio, N.; Blanco, J.; Perez, S.; Mateos, M.; Engel, E.
local.citation.publicationNameMaterials science & engineering. C, Biomimetic materials, sensors and systems
local.citation.volume121
local.citation.startingPage1111854:1
local.citation.endingPage111854:13


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