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Engineered microtissues for the bystander therapy against cancer

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10.1016/j.msec.2020.111854
 
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Blanco Fernández, BárbaraMés informació
Cano Torres, Irene
Garrido, Cristina
Rubi Sans, GerardMés informacióMés informació
Sanchez Cid, Lourdes
Guerra Rebollo, Marta
Rubio, Nuria
Blanco, Jeronimo
Pérez Amodio, Soledad GracielaMés informacióMés informació
Mateos Timoneda, Miguel ÁngelMés informació
Engel López, ElisabethMés informacióMés informacióMés informació
Document typeArticle
Defense date2021-02-01
PublisherElsevier
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Thymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this strategy requires multiple TK-hAMSCs administrations and a substantial number of cells. Therefore, for clinical translation, it is necessary to find a biocompatible scaffold providing TK-hAMSCs retention in the implantation site against their rapid wash-out. We have developed a microtissue (MT) composed by TKhAMSCs and a scaffold made of polylactic acid microparticles and cell-derived extracellular matrix deposited by hAMSCs. The efficacy of these MTs as vehicles for TK-hAMSCs/GCV bystander therapy was evaluated in a rodent model of human prostate cancer. Subcutaneously implanted MTs were integrated in the surrounding tissue, allowing neovascularization and maintenance of TK-hAMSCs viability. Furthermore, MTs implanted beside tumors allowed TK-hAMSCs migration towards tumor cells and, after GCV administration, inhibited tumor growth. These results indicate that TK-hAMSCs-MTs are promising cell reservoirs for clinical use of therapeutic MSCs in bystander therapies.
CitationBlanco Fernández, B. [et al.]. Engineered microtissues for the bystander therapy against cancer. "Materials science & engineering. C, Biomimetic materials, sensors and systems", 1 Febrer 2021, vol. 121, p. 1111854:1-111854:13. 
URIhttp://hdl.handle.net/2117/362135
DOI10.1016/j.msec.2020.111854
ISSN1873-0191
Publisher versionhttps://www.sciencedirect.com/science/article/abs/pii/S0928493120337735
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  • IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies - Articles de revista [385]
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  • Departament de Ciència i Enginyeria de Materials - Articles de revista [650]
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