Nano-engineering stable contact-based antimicrobials: Chemistry at the interface between nano-gold and bacteria
Visualitza/Obre
10.1016/j.colsurfb.2021.112083
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/359694
Tipus de documentArticle
Data publicació2021-12
EditorElsevier
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Contact-based antimicrobials, as antibiotic-free technologies that use non-specific interactions with bacterial
cells to exert antimicrobial activity, are a prospective solution in fighting the global issue of bacterial resistance.
A very simplified approach to their design considers the direct bonding of cationic guanidine-containing amino
acids to the surface of nano-gold carriers. The structure enables antimicrobial activity due to a high density of
cationic surface charges. This opens a set of novel questions that are important for their effective engineering,
particularly regarding (i) chemistry and events that take place at the interface between NPs and cells, (ii) the
direct influence of a charge (and its change) on interactions with bacterial and mammalian cells, and (iii) the
stability of structures (and their antimicrobial activity) in the presence of enzymes, which are addressed in this
paper. Because of the ability of amino acid-functionalized nano-gold to retain structural and functional activity,
even after exposure to a range of physicochemical stimuli, they provide an excellent nanotechnological platform
for designing highly effective contact-based antimicrobials and their applications.
CitacióVukomanovic, M. [et al.]. Nano-engineering stable contact-based antimicrobials: Chemistry at the interface between nano-gold and bacteria. "Colloids and Surfaces B. Biointerfaces", Desembre 2021, vol. 208, núm. 112083, p. 1-11.
ISSN0927-7765
Versió de l'editorhttps://www.sciencedirect.com/science/article/pii/S0927776521005270#!
Col·leccions
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
1-s2.0-S0927776521005270-main.pdf | 13,91Mb | Visualitza/Obre |