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dc.contributor.authorFerreres Cabanes, Guillem
dc.contributor.authorPérez Rafael, Silvia
dc.contributor.authorTorrent Burgués, Juan
dc.contributor.authorTzanov, Tzanko
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Polímers i Biopolímers
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2022-01-10T13:09:29Z
dc.date.available2022-01-10T13:09:29Z
dc.date.issued2021-12-14
dc.identifier.citationFerreres, G. [et al.]. Hyaluronic acid derivative molecular weight-dependent synthesis and antimicrobial effect of hybrid silver nanoparticles. "International journal of molecular sciences", 14 Desembre 2021, vol. 22, núm. 24, p. 13428:1-13428:14.
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/2117/359232
dc.description.abstractSilver nanoparticles (Ag NPs) appeared as promising antimicrobial candidates to face the development of antibiotic resistance. Although reported as toxic towards mammalian cells, their combination with biomolecules have shown reduced toxicity, while maintaining the antimicrobial function. Herein, hyaluronic acid (HA) with low (40 kDa), medium (200 and 600 kDa) and high (2 MDa) molecular weight (Mw) was modified with adipic acid dihydrazide (ADH) and used as reducing and capping agents to synthesise antimicrobial hybrid Ag NPs. The Mw of the polymer played a crucial role in the morphology, size and antibacterial activity of the Ag NPs. The 600 and 200 kDa HA-ADH-Ag NPs were able to reduce the Escherichia coli and Staphylococcus aureus concentration by more than 3 logs, while the 40 kDa NPs reached ~2 logs reduction. The 2 MDa HA-ADH failed to form homogenous NPs with strong bactericidal activity. A mechanistic study of the interaction with a model bacterial membrane using Langmuir isotherms confirmed the greater interaction between bacteria and higher Mw polymers and the effect of the NP’s morphology. The nanocomposites low toxicity to human skin cells was demonstrated in vitro, showing more than 90% cell viability after incubation with the NPs.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshHyaluronic acid
dc.subject.lcshAntibiotics
dc.subject.lcshNanoparticles
dc.subject.lcshSilver
dc.subject.otherHyaluronic acid
dc.subject.otherAdipic acid dihydrazide
dc.subject.otherSilver nanoparticles
dc.subject.otherPolymer molecular weight
dc.subject.otherAntimicrobial
dc.titleHyaluronic acid derivative molecular weight-dependent synthesis and antimicrobial effect of hybrid silver nanoparticles
dc.typeArticle
dc.subject.lemacÀcid hialurònic
dc.subject.lemacAntibiòtics
dc.subject.lemacNanopartícules
dc.subject.lemacPlata
dc.contributor.groupUniversitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.identifier.doi10.3390/ijms222413428
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/22/24/13428
dc.rights.accessOpen Access
local.identifier.drac32362693
dc.description.versionPostprint (published version)
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/720851/EU/Pre-commercial lines for production of surface nanostructured antimicrobial and anti-biofilm textiles, medical devices and water treatment membranes/PROTECT
local.citation.authorFerreres, G.; Perez, S.; Torrent-Burgués, J.; Tzanov, T.
local.citation.publicationNameInternational journal of molecular sciences
local.citation.volume22
local.citation.number24
local.citation.startingPage13428:1
local.citation.endingPage13428:14


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