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A biodegradable copolyester, poly(Butylene succinate-co-e-caprolactone), as a high efficiency matrix former for controlled release of drugs
dc.contributor.author | Galdón Navarro, Eduardo |
dc.contributor.author | Millán Jiménez, Mónica |
dc.contributor.author | Mora Castaño, Gloria |
dc.contributor.author | Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon |
dc.contributor.author | Caraballo Rodríguez, Isidoro |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2021-12-13T15:09:33Z |
dc.date.available | 2021-12-13T15:09:33Z |
dc.date.issued | 2021-07-01 |
dc.identifier.citation | Galdón, E. [et al.]. A biodegradable copolyester, poly(Butylene succinate-co-e-caprolactone), as a high efficiency matrix former for controlled release of drugs. "Pharmaceutics", 1 Juliol 2021, vol. 13, núm. 7, p. 1057:1-1057:15. |
dc.identifier.issn | 1999-4923 |
dc.identifier.uri | http://hdl.handle.net/2117/358265 |
dc.description.abstract | A biodegradable copolyester, poly(butylene succinate-co-e-caprolactone) (PBS_CL), was used for first time as an excipient for pharmaceutical dosage forms using direct compression and hot processing techniques (ultrasound-assisted compression (USAC) and hot melt extrusion (HME)). Robust binary systems were achieved with hot processing techniques, allowing a controlled release of the drug. With only 12% v/v of PBS_CL, controlled release forms were obtained using USAC whereas in HME over 34% v/v of excipient is necessary. Amounts over 23% v/v allowed a long-extended release for more than 72 h following diffusional kinetic. Thanks to the high melting point of theophylline and the physicochemical properties of PBS_CL selected and synthesized, the structure of the excipient inside the USAC tablets and HME filaments corresponds to a continuum medium. A percolation threshold around 23% v/v was estimated, which agrees with a continuum percolation model. The polymer shows a high excipient efficiency value using HME and USAC. A nanostructured matrix with wall thicknesses lower than 0.1 µm was obtained. This leads to a very effective coating of the drug particles by the excipient, providing a slow and reproducible release. The present study therefore supports the use of PBS_CL, for the preparation of controlled release dosage forms using hot processing techniques. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights | ©2021 MDPI |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | drugs -- Controlled release |
dc.subject.lcsh | Biomedical materials |
dc.subject.lcsh | Copolymers |
dc.subject.other | Poly(butylene succinate-co-e-caprolactone) |
dc.subject.other | Biodegradable polymer |
dc.subject.other | Ultrasound-assisted compression |
dc.subject.other | Hot melt extrusion |
dc.subject.other | Controlled release |
dc.subject.other | Nanostructured matrices |
dc.title | A biodegradable copolyester, poly(Butylene succinate-co-e-caprolactone), as a high efficiency matrix former for controlled release of drugs |
dc.type | Article |
dc.subject.lemac | Medicaments -- Alliberament retardat |
dc.subject.lemac | Materials biomèdics |
dc.subject.lemac | Copolímers |
dc.contributor.group | Universitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics |
dc.identifier.doi | 10.3390/pharmaceutics13071057 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/13/7/1057 |
dc.rights.access | Open Access |
local.identifier.drac | 32051887 |
dc.description.version | Postprint (published version) |
dc.relation.projectid | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095041-B-C33/ES/SISTEMAS DE LIBERACION DE FARMACOS BASADOS EN POLIMEROS AVANZADOS PARA EL TRATAMIENTO DE ENFERMEDADES GASTROINTESTINALES: POLIESTERES ANFIFILICOS Y BIOPOLIMEROS CARBOXILADOS/ |
local.citation.author | Galdón, E.; Millán, M.; Mora, G.; Martinez de Ilarduya, A.; Caraballo, I. |
local.citation.publicationName | Pharmaceutics |
local.citation.volume | 13 |
local.citation.number | 7 |
local.citation.startingPage | 1057:1 |
local.citation.endingPage | 1057:15 |
dc.description.sdg | Objectius de Desenvolupament Sostenible::3 - Salut i Benestar |
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