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Nanoparticle-driven self-assembling injectable hydrogels provide a multi-factorial approach for chronic wound treatment

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10.1016/j.actbio.2021.07.020
 
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hdl:2117/356125

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Pérez Rafael, SilviaMés informacióMés informació
Ivanova, Kristina DimitrovaMés informacióMés informacióMés informació
Stefanov, Ivaylo
Puiggalí Bellalta, JordiMés informacióMés informacióMés informació
Valle Mendoza, Luis Javier delMés informacióMés informacióMés informació
Todorova, Katerina
Dimitrov, Petar
Hinojosa Caballero, Dolores
Tzanov, TzankoMés informacióMés informacióMés informació
Document typeArticle
Defense date2021-07-14
PublisherElsevier
Rights accessRestricted access - publisher's policy (embargoed until 2023-10-23)
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
ProjectReInvent - Novel Products for Construction and Automotive Industries Based on Bio Materials and Natural Fibres (EC-H2020-792049)
RECUBRIMIENTOS DE HIDROGEL QUE CONTIENEN NANOPARTICULAS ANTIMICROBIANAS PARA COMBATIR INFECCIONES ASOCIADAS AL USO DE CATETERES POR BACTERIAS RESISTENTES A LOS ANTIBIOTICOS (AEI-PID2019-104111RB-I00)
Abstract
Chronic wounds represent a major health burden and drain on medical system. Efficient wound repair is only possible if the dressing materials target simultaneously multiple factors involved in wound chronicity, such as deleterious proteolytic and oxidative enzymes and high bacterial load. Here we develop multifunctional hydrogels for chronic wound management through self-assembling of thiolated hyaluronic acid (HA-SH) and bioactive silver-lignin nanoparticles (Ag@Lig NPs). Dynamic and reversible interactions between the polymer and Ag@Lig NPs yield hybrid nanocomposite hydrogels with shear thinning and self-healing properties, coupled to zero-order kinetics release of antimicrobial silver in response to infection-related hyaluronidase (HNase). The hydrogels inhibit the major enzymes myeloperoxidase (MPO) and matrix metalloproteinases (MMPs) responsible for wound chronicity in a patient’s wound exudate. Furthermore, the lignin-capped AgNPs provide the hydrogel with antioxidant properties and strong antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. The nanocomposite hydrogels are not toxic to human keratinocytes after 7 days of direct contact. Complete tissue remodeling and restoration of skin integrity is demonstrated in vivo in a diabetic mouse model. Hematological analysis reveals lack of wound inflammation due to bacterial infection or toxicity, confirming the potential of HA-SH/Ag@Lig NPs hydrogels for chronic wound management.
CitationPerez, S. [et al.]. Nanoparticle-driven self-assembling injectable hydrogels provide a multi-factorial approach for chronic wound treatment. "Acta biomaterialia", 14 Juliol 2021, vol. 134, núm. 15, p. 131-143. 
URIhttp://hdl.handle.net/2117/356125
DOI10.1016/j.actbio.2021.07.020
ISSN1742-7061
Publisher versionhttps://www.sciencedirect.com/science/article/abs/pii/S1742706121004517
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  • GBMI - Grup de Biotecnologia Molecular i Industrial - Articles de revista [170]
  • Departament d'Enginyeria Química - Articles de revista [1.990]
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