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dc.contributor.authorKonka, Joanna Magdalena
dc.contributor.authorBuxadera Palomero, Judit
dc.contributor.authorEspañol Pons, Montserrat
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Enginyeria Biomèdica
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials
dc.date.accessioned2021-11-02T12:29:08Z
dc.date.available2021-11-02T12:29:08Z
dc.date.issued2021-01-01
dc.identifier.citationKonka, J. [et al.]. 3D printing of hierarchical porous biomimetic hydroxyapatite scaffolds: Adding concavities to the convex filaments. "Acta biomaterialia", 1 Gener 2021, vol. 134, núm. 15, p. 744-759.
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/2117/355149
dc.description.abstractPorosity plays a key role on the osteogenic performance of bone scaffolds. Direct Ink Writing (DIW) allows the design of customized synthetic bone grafts with patient-specific architecture and controlled macroporosity. Being an extrusion-based technique, the scaffolds obtained are formed by arrays of cylindrical filaments, and therefore have convex surfaces. This may represent a serious limitation, as the role of surface curvature and more specifically the stimulating role of concave surfaces in osteoinduction and bone growth has been recently highlighted. Hence the need to design strategies that allow the introduction of concave pores in DIW scaffolds. In the current study, we propose to add gelatin microspheres as a sacrificial material in a self-setting calcium phosphate ink. Neither the phase transformation responsible for the hardening of the scaffold nor the formation of characteristic network of needle-like hydroxyapatite crystals was affected by the addition of gelatin microspheres. The partial dissolution of the gelatin resulted in the creation of spherical pores throughout the filaments and exposed on the surface, increasing filament porosity from 0.2 % to 67.9 %. Moreover, the presence of retained gelatin proved to have a significant effect on the mechanical properties, reducing the strength but simultaneously giving the scaffolds an elastic behavior, despite the high content of ceramic as a continuous phase. Notwithstanding the inherent difficulty of in vitro cultures with this highly reactive material an enhancement of MG-63 cell proliferation, as well as better spreading of hMSCs was recorded on the developed scaffolds.
dc.format.extent16 p.
dc.language.isoeng
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights2021. Elsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshHydroxyapatite
dc.subject.lcshBone regeneration
dc.subject.lcshThree-dimensional printing
dc.subject.other3D printing
dc.subject.otherHydroxyapatite
dc.subject.otherGelatin
dc.subject.otherBiomimetic
dc.subject.otherConcavity
dc.subject.otherBone regeneration
dc.subject.otherPorous filament
dc.title3D printing of hierarchical porous biomimetic hydroxyapatite scaffolds: Adding concavities to the convex filaments
dc.typeArticle
dc.subject.lemacHidroxiapatita
dc.subject.lemacOssos--Regeneració
dc.subject.lemacImpressió 3D
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1016/j.actbio.2021.07.071
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1742706121005092
dc.rights.accessOpen Access
local.identifier.drac32059594
dc.description.versionPostprint (published version)
dc.contributor.covenanteeInstitut de Bioenginyeria de Catalunya
local.citation.authorKonka, J.; Buxadera-Palomero, J.; Español, M.; Ginebra, M.P.
local.citation.publicationNameActa biomaterialia
local.citation.volume134
local.citation.number15
local.citation.startingPage744
local.citation.endingPage759


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