Biochemical model for the amoeboid motion of Dictyostelium discoideum cells
Tipus de documentProjecte Final de Màster Oficial
Data2020-09-07
Condicions d'accésAccés obert
Tots els drets reservats. Aquesta obra està protegida pels drets de propietat intel·lectual i
industrial corresponents. Sense perjudici de les exempcions legals existents, queda prohibida la seva
reproducció, distribució, comunicació pública o transformació sense l'autorització del titular dels drets
Abstract
Chemotaxis can be understood as the directed cell migration towards a nonisotropic chemoattractant gradient present in the surrounding environment. This response to external chemical stimuli is employed by eukaryotic cells as a central mechanism lying behind biological processes like development, immune response, and metastasis of tumor cells in multicellular tissues, or sourcing of food and formation of pluricellular structures in unicellular organisms. The focus of the following project stands on the model organism Dictyostelium discoideum. A biochemical model that pursue to elucidate the molecular mechanisms responsible for polarization of the cell and the locomotion in Dictyostelium cells during chemotaxis is studied. The starting point will be a simplified model of a conservative system based on a recent article from Fukushima et al. (2019), the latter is compound by two coupled networks describing complex interactions between certain phospholipids localized at cell membrane and enzymes from the cytosol. After reproducing gradually a complete model searching for excitability properties, it will be discussed the influence of such coupling on the system dynamics. Computational simulations of the spatiotemporal behavior in one and two dimensions were performed, using deterministic and stochastic equations, i.e. the Chemical Langevin equation. The incorporation of a dynamic phase field is employed to characterize the cell shape in two dimensions.
TitulacióMÀSTER UNIVERSITARI EN FÍSICA PER A L'ENGINYERIA (Pla 2018)
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
Biochemical mod ... elium discoideum cells.pdf | 5,529Mb | Visualitza/Obre |