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dc.contributor.authorRubi Sans, Gerard
dc.contributor.authorCano Garcia, Irene
dc.contributor.authorPérez Amodio, Soledad Graciela
dc.contributor.authorBlanco, Bárbara
dc.contributor.authorMateos Timoneda, Miguel Ángel
dc.contributor.authorEngel López, Elisabeth
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Enginyeria Biomèdica
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials
dc.date.accessioned2021-09-16T07:28:35Z
dc.date.available2021-09-16T07:28:35Z
dc.date.issued2021-02-25
dc.identifier.citationRubi-Sans, G. [et al.]. Development and angiogenic potential of cell-derived microtissues using microcarrier-template. "Biomedicines", 25 Febrer 2021, vol. 9, núm. 3, p. 232:1-232:18.
dc.identifier.issn2227-9059
dc.identifier.urihttp://hdl.handle.net/2117/351411
dc.description.abstractTissue engineering and regenerative medicine approaches use biomaterials in combination with cells to regenerate lost functions of tissues and organs to prevent organ transplantation. However, most of the current strategies fail in mimicking the tissue’s extracellular matrix properties. In order to mimic native tissue conditions, we developed cell-derived matrix (CDM) microtissues (MT). Our methodology uses poly-lactic acid (PLA) and Cultispher® S microcarriers’ (MCs’) as scaffold templates, which are seeded with rat bone marrow mesenchymal stem cells (rBM-MSCs). The scaffold template allows cells to generate an extracellular matrix, which is then extracted for downstream use. The newly formed CDM provides cells with a complex physical (MT architecture) and biochemical (deposited ECM proteins) environment, also showing spontaneous angiogenic potential. Our results suggest that MTs generated from the combination of these two MCs (mixed MTs) are excellent candidates for tissue vascularization. Overall, this study provides a methodology for in-house fabrication of microtissues with angiogenic potential for downstream use in various tissue regenerative strategies.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivates 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials
dc.subject.lcshTissue engineering
dc.subject.lcshRegenerative medicine
dc.subject.lcshBiomedical materials
dc.subject.otherPoly-lactic acid microcarriers
dc.subject.otherCultispher® S
dc.subject.otherRat bone marrow mesenchymal stem cells
dc.subject.otherMicrotissue
dc.subject.otherCell-derived matrix
dc.subject.otherAngiogenesis
dc.titleDevelopment and angiogenic potential of cell-derived microtissues using microcarrier-template
dc.typeArticle
dc.subject.lemacEnginyeria de teixits
dc.subject.lemacMedicina regenerativa
dc.subject.lemacMaterials biomèdics
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
dc.identifier.doi10.3390/biomedicines9030232
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.mdpi.com/2227-9059/9/3/232
dc.rights.accessOpen Access
local.identifier.drac31966799
dc.description.versionPostprint (published version)
local.citation.authorRubi-Sans, G.; Cano, I.G.; Perez, S.; Blanco, B.; Mateos, M.; Engel, E.
local.citation.publicationNameBiomedicines
local.citation.volume9
local.citation.number3
local.citation.startingPage232:1
local.citation.endingPage232:18


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