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Development and angiogenic potential of cell-derived microtissues using microcarrier-template

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biomedicines-09-00232-v3.pdf (6,157Mb)
 
10.3390/biomedicines9030232
 
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hdl:2117/351411

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Rubí Sans, GerardMés informacióMés informació
Cano Garcia, Irene
Pérez Amodio, Soledad GracielaMés informacióMés informació
Blanco, Bárbara
Mateos Timoneda, Miguel ÁngelMés informació
Engel López, ElisabethMés informacióMés informacióMés informació
Document typeArticle
Defense date2021-02-25
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 4.0 International
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 4.0 International
Abstract
Tissue engineering and regenerative medicine approaches use biomaterials in combination with cells to regenerate lost functions of tissues and organs to prevent organ transplantation. However, most of the current strategies fail in mimicking the tissue’s extracellular matrix properties. In order to mimic native tissue conditions, we developed cell-derived matrix (CDM) microtissues (MT). Our methodology uses poly-lactic acid (PLA) and Cultispher® S microcarriers’ (MCs’) as scaffold templates, which are seeded with rat bone marrow mesenchymal stem cells (rBM-MSCs). The scaffold template allows cells to generate an extracellular matrix, which is then extracted for downstream use. The newly formed CDM provides cells with a complex physical (MT architecture) and biochemical (deposited ECM proteins) environment, also showing spontaneous angiogenic potential. Our results suggest that MTs generated from the combination of these two MCs (mixed MTs) are excellent candidates for tissue vascularization. Overall, this study provides a methodology for in-house fabrication of microtissues with angiogenic potential for downstream use in various tissue regenerative strategies.
CitationRubi-Sans, G. [et al.]. Development and angiogenic potential of cell-derived microtissues using microcarrier-template. "Biomedicines", 25 Febrer 2021, vol. 9, núm. 3, p. 232:1-232:18. 
URIhttp://hdl.handle.net/2117/351411
DOI10.3390/biomedicines9030232
ISSN2227-9059
Publisher versionhttps://www.mdpi.com/2227-9059/9/3/232
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  • IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies - Articles de revista [447]
  • Doctorat en Enginyeria Biomèdica - Articles de revista [126]
  • Departament de Ciència i Enginyeria de Materials - Articles de revista [922]
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