Biocompatible graft copolymers from bacterial poly(gamma-glutamic acid) and poly(lactic acid)
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Document typeArticle
Defense date2021-07-14
Rights accessRestricted access - publisher's policy
(embargoed until 2022-06-09)
Abstract
We report a novel approach for the modular and convergent construction of biocompatible graft copolymers starting from bacterial poly(¿-glutamic acid)(¿-PGA) and incorporating poly(lactic acid) (PLA). This synthesis strategy is controlled at different levels: (a) the choice of a suitable initiator for the ring-opening polymerization of lactide; (b) the chemical elaboration of the polylactic fragments; and (c) their convergent “grafting to” functionalization of bacterial ¿-PGA propargyl ester using copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC) click chemistry. The graft copolymers are characterized in terms of their thermal and macromolecular properties, their conformational preferences through molecular modelling, and their cytotoxicity.
CitationZaccaria, C. [et al.]. Biocompatible graft copolymers from bacterial poly(gamma-glutamic acid) and poly(lactic acid). "Polymer chemistry", 14 Juliol 2021, vol. 12, núm. 26, p. 3784-3793.
ISSN1759-9954
Publisher versionhttps://pubs.rsc.org/en/content/articlelanding/2021/py/d1py00737h
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