Zn-Mg and Zn-Cu alloys for stenting applications: From nanoscale mechanical characterization to in vitro degradation and biocompatibility
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10.1016/j.bioactmat.2021.04.015
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/350754
Realitzat a/ambInstitut de Bioenginyeria de Catalunya
Tipus de documentArticle
Data publicació2021-12
Condicions d'accésAccés obert
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continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
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Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
In the recent decades, zinc (Zn) and its alloys have been drawing attention as promising candidates for bioresorbable cardiovascular stents due to its degradation rate more suitable than magnesium (Mg) and iron (Fe) alloys. However, its mechanical properties need to be improved in order to meet the criteria for vascular stents. This work investigates the mechanical properties, biodegradability and biocompatibility of Zn-Mg and Zn-Cu alloys in order to determine a proper alloy composition for optimal stent performance. Nanoindentation measurements are performed to characterize the mechanical properties at the nanoscale as a function of the Zn microstructure variations induced by alloying. The biodegradation mechanisms are discussed and correlated to microstructure, mechanical performance and bacterial/cell response. Addition of Mg or Cu alloying elements refined the microstructure of Zn and enhanced yield strength (YS) and ultimate tensile strength (UTS) proportional to the volume fraction of secondary phases. Zn-1Mg showed the higher YS and UTS and better performance in terms of degradation stability in Hanks’ solution. Zn-Cu alloys presented an antibacterial effect for S. aureus controlled by diffusion mechanisms and by contact. Biocompatibility was dependent on the degradation rate and the nature of the corrosion products.
CitacióGarcía-Mintegui, C. [et al.]. Zn-Mg and Zn-Cu alloys for stenting applications: From nanoscale mechanical characterization to in vitro degradation and biocompatibility. "Bioactive Materials", Desembre 2021, vol. 6, núm. 12, p. 4430-4446.
ISSN2452-199X
Versió de l'editorhttps://www.sciencedirect.com/science/article/pii/S2452199X21001845
Col·leccions
- Departament de Ciència i Enginyeria de Materials - Articles de revista [729]
- CIEFMA - Centre d'Integritat Estructural, Fiabilitat i Micromecànica dels Materials - Articles de revista [283]
- Doctorat en Ciència i Enginyeria dels Materials - Articles de revista [155]
- R2EM - Resource Recovery and Environmental Management - Articles de revista [208]
- Departament d'Enginyeria Química - Articles de revista [2.214]
- BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits - Articles de revista [438]
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