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dc.contributor.authorFernández González, Pol
dc.contributor.authorMas Sánchez, Aina
dc.contributor.authorGarriga Solé, Pere
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Tecnologia Agroalimentària i Biotecnologia
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2021-07-16T11:08:49Z
dc.date.available2021-07-16T11:08:49Z
dc.date.issued2021-06-04
dc.identifier.citationFernandez, P.; Mas, A.; Garriga, P. Polyphenols and visual health: potential effects on degenerative retinal diseases. "Molecules", 4 Juny 2021, vol. 26, núm. 11, art. 3407.
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/2117/349543
dc.description.abstractDietary polyphenols are a group of natural compounds that have been proposed to have beneficial effects on human health. They were first known for their antioxidant properties, but several studies over the years have shown that these compounds can exert protective effects against chronic diseases. Nonetheless, the mechanisms underlying these potential benefits are still uncertain and contradictory effects have been reported. In this review, we analyze the potential effects of polyphenol compounds on some visual diseases, with a special focus on retinal degenerative diseases. Current effective therapies for the treatment of such retinal diseases are lacking and new strategies need to be developed. For this reason, there is currently a renewed interest in finding novel ligands (or known ligands with previously unexpected features) that could bind to retinal photoreceptors and modulate their molecular properties. Some polyphenols, especially flavonoids (e.g., quercetin and tannic acid), could attenuate light-induced receptor damage and promote visual health benefits. Recent evidence suggests that certain flavonoids could help stabilize the correctly folded conformation of the visual photoreceptor protein rhodopsin and offset the deleterious effect of retinitis pigmentosa mutations. In this regard, certain polyphenols, like the flavonoids mentioned before, have been shown to improve the stability, expression, regeneration and folding of rhodopsin mutants in experimental in vitro studies. Moreover, these compounds appear to improve the integration of the receptor into the cell membrane while acting against oxidative stress at the same time. We anticipate that polyphenol compounds can be used to target visual photoreceptor proteins, such as rhodopsin, in a way that has only been recently proposed and that these can be used in novel approaches for the treatment of retinal degenerative diseases like retinitis pigmentosa; however, studies in this field are limited and further research is needed in order to properly characterize the effects of these compounds on retinal degenerative diseases through the proposed mechanisms
dc.language.isoeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectÀrees temàtiques de la UPC::Ciències de la visió::Biologia ocular
dc.subject.lcshRetinal degeneration
dc.subject.lcshRetinitis pigmentosa
dc.subject.lcshFlavonoids
dc.subject.lcshRhodopsin
dc.subject.otherFlavonoids
dc.subject.otherRetinal degenerative diseases
dc.subject.otherRetinitis pigmentosa
dc.subject.otherProtein folding
dc.subject.otherLigand binding
dc.subject.otherRhodopsin
dc.titlePolyphenols and visual health: potential effects on degenerative retinal diseases
dc.typeArticle
dc.subject.lemacDegeneració macular
dc.subject.lemacRetinitis pigmentària
dc.subject.lemacFlavonoides
dc.subject.lemacRodopsina
dc.contributor.groupUniversitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.identifier.doi10.3390/molecules26113407
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/26/11/3407
dc.rights.accessOpen Access
local.identifier.drac31901138
dc.description.versionPostprint (published version)
dc.relation.projectidinfo:eu-repo/grantAgreement/AEI/1PE/ PID2019-104817GB-I00
local.citation.authorFernandez, P.; Mas, A.; Garriga, P.
local.citation.publicationNameMolecules
local.citation.volume26
local.citation.number11
local.citation.startingPage3407-1
local.citation.endingPage3407-20


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Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution 4.0 Generic