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Functionalization strategies and fabrication of solvent-cast PLLA for bioresorbable stents
dc.contributor.author | Schieber, Romain |
dc.contributor.author | Raymond Llorens, Santiago |
dc.contributor.author | Caparrós, Cristina |
dc.contributor.author | Bou Serra, Jordi |
dc.contributor.author | Herrero Acero, Enrique |
dc.contributor.author | Guebitz, Georg |
dc.contributor.author | Canal Barnils, Cristina |
dc.contributor.author | Pegueroles Neyra, Marta |
dc.contributor.other | Universitat Politècnica de Catalunya. Doctorat en Ciència i Enginyeria dels Materials |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials |
dc.date.accessioned | 2021-05-12T12:39:40Z |
dc.date.available | 2021-05-12T12:39:40Z |
dc.date.issued | 2021-02-06 |
dc.identifier.citation | Schieber, R. [et al.]. Functionalization strategies and fabrication of solvent-cast PLLA for bioresorbable stents. "Applied sciences", 6 Febrer 2021, vol. 11, núm. 4, p. 1478:1-1478:18. |
dc.identifier.issn | 2076-3417 |
dc.identifier.uri | http://hdl.handle.net/2117/345509 |
dc.description.abstract | Actual polymer bioresorbable stents (BRS) generate a risk of device thrombosis as a consequence of the incomplete endothelialization after stent implantation. The material-tissue interactions are not fully controlled and stent fabrication techniques do not allow personalized medical solutions. This work investigates the effect of different functionalization strategies onto solvent-cast poly(l-lactic acid) (PLLA) surfaces with the capacity to enhance surface endothelial adhesion and the fabrication of 3D printed BRS. PLLA films were obtained by solvent casting and treated thermally to increase mechanical properties. Surface functionalization was performed by oxygen plasma (OP), sodium hydroxide (SH) etching, or cutinase enzyme (ET) hydrolysis, generating hydroxyl and carboxyl groups. A higher amount of carboxyl and hydroxyl groups was determined on OP and ET compared to the SH surfaces, as determined by contact angle and X-ray photoelectron spectroscopy (XPS). Endothelial cells (ECs) adhesion and spreading was higher on OP and ET functionalized surfaces correlated with the increase of functional groups without affecting the degradation. To verify the feasibility of the approach proposed, 3D printed PLLA BRS stents were produced by the solvent-cast direct writing technique |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Biocompatibilitat |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Polímers en medicina |
dc.subject.lcsh | Biomedical materials |
dc.subject.other | Poly(l-lactic acid) solvent casting |
dc.subject.other | Surface modification |
dc.subject.other | Cold atmospheric plasma |
dc.subject.other | Cutinase enzyme |
dc.subject.other | Biocompatibility |
dc.subject.other | 3D printed stent |
dc.title | Functionalization strategies and fabrication of solvent-cast PLLA for bioresorbable stents |
dc.type | Article |
dc.subject.lemac | Polímers en medicina |
dc.subject.lemac | Stents |
dc.subject.lemac | Materials biomèdics |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.3390/app11041478 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://www.mdpi.com/2076-3417/11/4/1478 |
dc.rights.access | Open Access |
local.identifier.drac | 30863842 |
dc.description.version | Postprint (published version) |
dc.contributor.covenantee | Austrian Centre of Industrial Biotechnology |
dc.contributor.covenantee | BOKU Universität für Bodenkultur Wien |
local.citation.author | Schieber, R.; Raymond, S.; Caparrós, C.; Bou, J. J.; Herrero , E.; Guebitz, G.; Canal, C.; Pegueroles, Marta |
local.citation.publicationName | Applied sciences |
local.citation.volume | 11 |
local.citation.number | 4 |
local.citation.startingPage | 1478:1 |
local.citation.endingPage | 1478:18 |
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