Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster
10.1080/22221751.2021.1913974
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/345496
Tipus de documentArticle
Data publicació2021
EditorTaylor & Francis Open Access
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial 3.0 Espanya
Abstract
Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question of immunity generated by a single infection is sufficient to provide sterilizing/protective immunity to a subsequent SARS-CoV-2 re-exposure. The Golden Syrian hamster is a manageable animal model to explore immunological mechanisms able to counteract COVID-19, as it recapitulates pathological aspects of mild to moderately affected patients. Here, we report that SARS-CoV-2-inoculated hamsters resolve infection in the upper and lower respiratory tracts within seven days upon inoculation with the Cat01 (G614) SARS-CoV-2 isolate. Three weeks after the primary challenge, and despite high titres of neutralizing antibodies, half of the animals were susceptible to reinfection by both identical (Cat01, G614) and variant (WA/1, D614) SARS-CoV-2 isolates. However, upon re-inoculation, only nasal tissues were transiently infected with much lower viral replication than those observed after the first inoculation. These data indicate that a primary SARS-CoV-2 infection is not sufficient to elicit a sterilizing immunity in hamster models but protects against lung disease.
CitacióBrustolin, M. [et al.]. Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster. "Emerging Microbes and Infections", 2021, vol. 10, núm. 1, p. 797-809.
ISSN2222-1751
Versió de l'editorhttps://doi.org/10.1080/22221751.2021.1913974
Col·leccions
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
Protection agai ... golden Syrian hamster.pdf | 2,523Mb | Visualitza/Obre |