A versatile click chemistry-based approach for functionalizing biomaterials of diverse nature with bioactive peptides

Cita com:
hdl:2117/344637
Document typeArticle
Defense date2021-01-25
Rights accessOpen Access
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Except where otherwise noted, its contents are licensed under a Creative Commons license
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Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
A novel and versatile toolkit approach for the functionalization of biomaterials of different nature is described. This methodology is based on the solid-phase conjugation of specific anchoring units onto a resin-bound azido-functionalized peptide by using click chemistry. A synergistic multifunctional peptidic scaffold with cell adhesive properties was used as a model compound to showcase the versatility of this new approach. Titanium, gold and polylactic acid surfaces were biofunctionalized by this method, as validated by physicochemical surface characterization with XPS. In vitro assays using mesenchymal stem cells showed enhanced cell adhesion on the functionalized samples, proving the capacity of this strategy to efficiently bioactivate different types of biomaterials
CitationMartin, H. [et al.]. A versatile click chemistry-based approach for functionalizing biomaterials of diverse nature with bioactive peptides. "Chemical communications (Cambridge, England)", 25 Gener 2021, vol. 57, p. 982-985.
ISSN1364-548X
Publisher versionhttps://pubs.rsc.org/en/content/articlelanding/2021/CC/D0CC07463B
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