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dc.contributor.authorGraffelman, Jan
dc.contributor.authorOrtoleva, Leonardo
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.identifier.citationGraffelman, J.; Ortoleva, L. A network algorithm for the X chromosomal exact test for Hardy–Weinberg equilibrium with multiple alleles. "Molecular ecology resources", 23 Març 2021,
dc.description.abstractStatistical methodology for testing the Hardy-Weinberg equilibrium at X chromosomal variants has recently experienced considerable development. Up to a few years ago, testing X chromosomal variants for equilibrium was basically done by applying autosomal test procedures to females only. At present, male alleles can be taken into account in asymptotic and exact test procedures for both the bi-and multiallelic case. However, current X chromosomal exact procedures for multiple alleles rely on a classical full enumeration algorithm and are computationally expensive, and in practice not feasible for more than three alleles. In this article, we extend the autosomal network algorithm for exact Hardy-Weinberg testing with multiple alleles to the X chromosome, achieving considerable reduction in computation times for multiallelic variants with up to five alleles. The performance of the X chromosomal network algorithm is assessed in a simulation study. Beyond four alleles, a permutation test is, in general, the more feasible approach. A detailed description of the algorithm is given, and examples of X chromosomal indels and microsatellites are discussed.
dc.description.sponsorshipThis work was supported by grant RTI2018‐095518‐B‐C22 (MCIU/AEI/FEDER) of the Spanish Ministry of Science, Innovation and Universities and the European Regional Development Fund, and by grant R01 GM075091 from the United States National Institutes of Health. We thank three anonymous reviewers whose comments have helped us to improve the article.
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica
dc.subject.lcshNumerical analysis--Simulation methods
dc.subject.otherHardy-Weinberg equilibrium
dc.subject.otherNetwork algorithm
dc.subject.otherPermutation test
dc.subject.otherX chromosome
dc.titleA network algorithm for the X chromosomal exact test for Hardy–Weinberg equilibrium with multiple alleles
dc.subject.lemacAnàlisi numèrica
dc.contributor.groupUniversitat Politècnica de Catalunya. COSDA-UPC - COmpositional and Spatial Data Analysis
dc.description.peerreviewedPeer Reviewed
dc.subject.amsClassificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general
dc.subject.amsClassificació AMS::65 Numerical analysis::65C Probabilistic methods, simulation and stochastic differential equations
dc.rights.accessOpen Access
dc.description.versionPostprint (author's final draft)
dc.relation.projectidinfo:eu-repo/grantAgreement/MICINN/1PE/ RTI2018-095518-B-C22
local.citation.authorGraffelman, J.; Ortoleva, L.
local.citation.publicationNameMolecular ecology resources

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