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A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome
dc.contributor.author | Khannous Lleiffe, Olfat |
dc.contributor.author | Willis, Jesse R. |
dc.contributor.author | Saus, Ester |
dc.contributor.author | Cabrera Aguilera, Ignacio |
dc.contributor.author | Almendros, Isaac |
dc.contributor.author | Farré, Ramon |
dc.contributor.author | Gozal, David |
dc.contributor.author | Farré, Nuria |
dc.contributor.author | Gabaldón, Toni |
dc.date.accessioned | 2021-04-14T15:19:11Z |
dc.date.available | 2021-04-14T15:19:11Z |
dc.date.issued | 2021 |
dc.identifier.citation | Khannous Lleiffe, O. [et al.]. A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome. "Microorganisms", 2021, vol. 9, núm. 3, 641. |
dc.identifier.issn | 2076-2607 |
dc.identifier.uri | http://hdl.handle.net/2117/343746 |
dc.description.abstract | Heart failure (HF) is a common condition associated with a high rate of hospitalizations and adverse outcomes. HF is characterized by impairments of either the cardiac ventricular filling, ejection of blood capacity or both. Sleep fragmentation (SF) involves a series of short sleep interruptions that lead to fatigue and contribute to cognitive impairments and dementia. Both conditions are known to be associated with increased inflammation and dysbiosis of the gut microbiota. In the present study, mice were distributed into four groups, and subjected for four weeks to either HF, SF, both HF and SF, or left unperturbed as controls. We used 16S metabarcoding to assess fecal microbiome composition before and after the experiments. Evidence for distinct alterations in several bacterial groups and an overall decrease in alpha diversity emerged in HF and SF treatment groups. Combined HF and SF conditions, however, showed no synergism, and observed changes were not always additive, suggesting preliminarily that some of the individual effects of either HF or SF cancel each other out when applied concomitantly |
dc.description.sponsorship | I.C.-A. was supported by CONICYT PFCHA—Chilean Doctorate Fellowship 2017; Grant No. 72180089. R.F. was supported in part by the Spanish Ministry of Economy and Competitiveness (SAF2017-85574-R). D.G. was supported in part by National Institutes of Health grants HL130984 and HL140548. T.G. group acknowledges support from the Spanish Ministry of Science and Innovation for grant PGC2018-099921-B-I00, cofounded by European Regional Development Fund (ERDF); from the CERCA Programme/Generalitat de Catalunya; from the Catalan Research Agency (AGAUR) SGR423. from the European Union’s Horizon 2020 research and innovation programme under the grant agreement ERC-2016-724173; and from Instituto de Salud Carlos III (INB Grant, PT17/0009/0023-ISCIII-SGEFI/ERDF). |
dc.format.extent | 16 p. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.rights | Attribution 3.0 Spain |
dc.rights | Attribution 4.0 International (CC BY 4.0) |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ |
dc.subject | Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica |
dc.subject.lcsh | Heart failure |
dc.subject.lcsh | Comorbidity |
dc.subject.lcsh | Sleep apnea syndromes |
dc.subject.other | Metagenomics |
dc.subject.other | Microbiome |
dc.subject.other | Sleep fragmentation |
dc.subject.other | Heart failure |
dc.subject.other | Sleep apnea |
dc.title | A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome |
dc.type | Article |
dc.subject.lemac | Infart de miocardi |
dc.identifier.doi | 10.3390/microorganisms9030641 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://www.mdpi.com/2076-2607/9/3/641 |
dc.rights.access | Open Access |
dc.description.version | Postprint (published version) |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/H2020/724173/EU/Reticulate evolution: patterns and impacts of non-vertical inheritance in eukaryotic genomes./RETVOLUTION |
local.citation.other | 641 |
local.citation.publicationName | Microorganisms |
local.citation.volume | 9 |
local.citation.number | 3 |
dc.identifier.pmid | 33808770 |
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