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dc.contributor.authorKhannous Lleiffe, Olfat
dc.contributor.authorWillis, Jesse R.
dc.contributor.authorSaus, Ester
dc.contributor.authorCabrera Aguilera, Ignacio
dc.contributor.authorAlmendros, Isaac
dc.contributor.authorFarré, Ramon
dc.contributor.authorGozal, David
dc.contributor.authorFarré, Nuria
dc.contributor.authorGabaldón, Toni
dc.date.accessioned2021-04-14T15:19:11Z
dc.date.available2021-04-14T15:19:11Z
dc.date.issued2021
dc.identifier.citationKhannous Lleiffe, O. [et al.]. A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome. "Microorganisms", 2021, vol. 9, núm. 3, 641.
dc.identifier.issn2076-2607
dc.identifier.urihttp://hdl.handle.net/2117/343746
dc.description.abstractHeart failure (HF) is a common condition associated with a high rate of hospitalizations and adverse outcomes. HF is characterized by impairments of either the cardiac ventricular filling, ejection of blood capacity or both. Sleep fragmentation (SF) involves a series of short sleep interruptions that lead to fatigue and contribute to cognitive impairments and dementia. Both conditions are known to be associated with increased inflammation and dysbiosis of the gut microbiota. In the present study, mice were distributed into four groups, and subjected for four weeks to either HF, SF, both HF and SF, or left unperturbed as controls. We used 16S metabarcoding to assess fecal microbiome composition before and after the experiments. Evidence for distinct alterations in several bacterial groups and an overall decrease in alpha diversity emerged in HF and SF treatment groups. Combined HF and SF conditions, however, showed no synergism, and observed changes were not always additive, suggesting preliminarily that some of the individual effects of either HF or SF cancel each other out when applied concomitantly
dc.description.sponsorshipI.C.-A. was supported by CONICYT PFCHA—Chilean Doctorate Fellowship 2017; Grant No. 72180089. R.F. was supported in part by the Spanish Ministry of Economy and Competitiveness (SAF2017-85574-R). D.G. was supported in part by National Institutes of Health grants HL130984 and HL140548. T.G. group acknowledges support from the Spanish Ministry of Science and Innovation for grant PGC2018-099921-B-I00, cofounded by European Regional Development Fund (ERDF); from the CERCA Programme/Generalitat de Catalunya; from the Catalan Research Agency (AGAUR) SGR423. from the European Union’s Horizon 2020 research and innovation programme under the grant agreement ERC-2016-724173; and from Instituto de Salud Carlos III (INB Grant, PT17/0009/0023-ISCIII-SGEFI/ERDF).
dc.format.extent16 p.
dc.language.isoeng
dc.publisherMDPI
dc.rightsAttribution 3.0 Spain
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectÀrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
dc.subject.lcshHeart failure
dc.subject.lcshComorbidity
dc.subject.lcshSleep apnea syndromes
dc.subject.otherMetagenomics
dc.subject.otherMicrobiome
dc.subject.otherSleep fragmentation
dc.subject.otherHeart failure
dc.subject.otherSleep apnea
dc.titleA mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome
dc.typeArticle
dc.subject.lemacInfart de miocardi
dc.identifier.doi10.3390/microorganisms9030641
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.mdpi.com/2076-2607/9/3/641
dc.rights.accessOpen Access
dc.description.versionPostprint (published version)
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/724173/EU/Reticulate evolution: patterns and impacts of non-vertical inheritance in eukaryotic genomes./RETVOLUTION
local.citation.other641
local.citation.publicationNameMicroorganisms
local.citation.volume9
local.citation.number3
dc.identifier.pmid33808770


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