Development of a new 3D hybrid model for epithelia morphogenesis
Cita com:
hdl:2117/342609
Tipus de documentArticle
Data publicació2020-05-05
EditorFrontiers Media SA
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Many epithelial developmental processes like cell migration and spreading, cell sorting, or T1 transitions can be described as planar deformations. As such, they can be studied using two-dimensional tools and vertex models that can properly predict collective dynamics. However, many other epithelial shape changes are characterized by out-of-plane mechanics and three-dimensional effects, such as bending, cell extrusion, delamination, or invagination. Furthermore, during planar cell dynamics or tissue repair in monolayers, spatial intercalation between the apical and basal sides has even been detected. Motivated by this lack of symmetry with respect to the midsurface, we here present a 3D hybrid model that allows us to model differential contractility at the apical, basal or lateral sides. We use the model to study the effects on wound closure of solely apical or lateral contractile contributions and show that an apical purse-string can be sufficient for full closure when it is accompanied by volume preservation.
CitacióIoannou, F. [et al.]. Development of a new 3D hybrid model for epithelia morphogenesis. "Frontiers in Bioengineering and Biotechnology", 5 Maig 2020, vol. 8, p. 1-22.
ISSN2296-4185
Versió de l'editorhttps://www.frontiersin.org/articles/10.3389/fbioe.2020.00405/full
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
2020-FBB-IDTMM.pdf | Post Print de Ioannou et al., Frontiers in Bioengin. and Biotech., 2020. | 5,227Mb | Visualitza/Obre |