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dc.contributor.authorZygouri, Panagiota
dc.contributor.authorSpyrou, Konstantinos
dc.contributor.authorMitsari, Efstratia
dc.contributor.authorBarrio Casado, María del
dc.contributor.authorMacovez, Roberto
dc.contributor.authorPatila, Michaela
dc.contributor.authorStamatis, Haralambo
dc.contributor.authorVerginadis, Ioannis
dc.contributor.authorVelalopoulou, Anastasia
dc.contributor.authorEvangelou, Angelos
dc.contributor.authorSideratou, Zili
dc.contributor.authorGournis, Dimitrios
dc.contributor.authorRudolf, Petra
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.date.accessioned2021-03-26T13:40:52Z
dc.date.available2021-03-26T13:40:52Z
dc.date.issued2020-12-01
dc.identifier.citationZygouri, P. [et al.]. A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems. "Scientific reports", 1 Desembre 2020, vol. 10, p. 8244:1-8244:13.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/2117/342606
dc.description.abstractA facile, environment-friendly, versatile and reproducible approach to the successful oxidation of fullerenes (oxC60) and the formation of highly hydrophilic fullerene derivatives is introduced. This synthesis relies on the widely known Staudenmaier’s method for the oxidation of graphite, to produce both epoxy and hydroxy groups on the surface of fullerenes (C60) and thereby improve the solubility of the fullerene in polar solvents (e.g. water). The presence of epoxy groups allows for further functionalization via nucleophilic substitution reactions to generate new fullerene derivatives, which can potentially lead to a wealth of applications in the areas of medicine, biology, and composite materials. In order to justify the potential of oxidized C60 derivatives for bio-applications, we investigated their cytotoxicity in vitro as well as their utilization as support in biocatalysis applications, taking the immobilization of laccase for the decolorization of synthetic industrial dyes as a trial case.
dc.language.isoeng
dc.publisherNature
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Física
dc.subject.lcshFullerenes
dc.titleA facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
dc.typeArticle
dc.subject.lemacFul·lerens
dc.contributor.groupUniversitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
dc.identifier.doi10.1038/s41598-020-65117-7
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-020-65117-7
dc.rights.accessOpen Access
local.identifier.drac28979393
dc.description.versionPostprint (published version)
local.citation.authorZygouri, P.; Spyrou, K.; Mitsari, E.; Del Barrio, M.; Macovez, R.; Patila, M.; Stamatis, H.; Verginadis, I. I.; Velalopoulou, A. P.; Evangelou, A. M.; Sideratou, Z.; Gournis, D.; Rudolf, P.
local.citation.publicationNameScientific reports
local.citation.volume10
local.citation.startingPage8244:1
local.citation.endingPage8244:13


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