Discovery of a bradykinin b2 partial agonist profile of raloxifene in a drug repurposing campaign
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Covid-19 urges a deeper understanding of the underlying molecular mechanisms involved in illness progression to provide a prompt therapeutical response with an adequate use of available drugs, including drug repurposing. Recently, it was suggested that a dysregulated bradykinin signaling can trigger the cytokine storm observed in patients with severe Covid-19. In the scope of a drug repurposing campaign undertaken to identify bradykinin antagonists, raloxifene was identified as prospective compound in a virtual screening process. The pharmacodynamics profile of raloxifene towards bradykinin receptors is reported in the present work, showing a weak selective partial agonist profile at the B2 receptor. In view of this new profile, its possible use as a therapeutical agent for the treatment of severe Covid-19 is discussed
CitationGomez, P.; Perez, J. Discovery of a bradykinin b2 partial agonist profile of raloxifene in a drug repurposing campaign. "International journal of molecular sciences", 29 Desembre 2020, vol. 22, núm. 1, p. 257:1-257:8.