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The eTRANSAFE project on translational safety assessment through integrative knowledge management: achievements and perspectives

dc.contributor.authorPognan, François
dc.contributor.authorSteger-Hartmann, Thomas
dc.contributor.authorDíaz, Carlos
dc.contributor.authorBlomberg, Niklas
dc.contributor.authorBringezu, Frank
dc.contributor.authorBriggs, Katharine
dc.contributor.authorCallegaro, Giulia
dc.contributor.authorCapella Gutiérrez, Salvador
dc.contributor.authorCenteno, Emilio
dc.contributor.authorCorvi, Javier
dc.contributor.authorDrew, Philip
dc.contributor.authorDrewe, William C.
dc.contributor.authorFernández González, Jose María
dc.contributor.authorFurlong, Laura I.
dc.contributor.authorGuney, Emre
dc.contributor.authorKors, Jan A.
dc.contributor.authorMayer, Miguel Angel
dc.contributor.authorPastor, Manuel
dc.contributor.authorPiñero, Janet
dc.contributor.authorRamírez-Anguita, Juan Manuel
dc.contributor.authorRonzano, Francesco
dc.contributor.authorRowell, Philip
dc.contributor.authorSaüch-Pitarch, Josep
dc.contributor.authorValencia, Alfonso
dc.contributor.authorWater, Bob van de
dc.contributor.authorLei, Johan van der
dc.contributor.authorMulligen, Erik van
dc.contributor.authorSanz, Ferran
dc.contributor.otherBarcelona Supercomputing Center
dc.date.accessioned2021-03-17T16:29:04Z
dc.date.available2021-03-17T16:29:04Z
dc.date.issued2021
dc.identifier.citationPognan, F. [et al.]. The eTRANSAFE project on translational safety assessment through integrative knowledge management: achievements and perspectives. "Pharmaceuticals", 2021, vol. 14, núm. 3, 237.
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/2117/341905
dc.description.abstracteTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events.
dc.description.sponsorshipThis research received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreements eTRANSAFE (777365). This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA companies in kind contribution. The Research Programme on Biomedical Informatics (GRIB) of IMIM and DCEXS-UPF is a member of the Spanish National Bioinformatics Institute (INB), PRB2-ISCIII and is supported by grant PT13/0001/0023, of the PE I + D + i 2013–2016, funded by ISCIII and FEDER. The GRIB also receive support from Agència de Gestió D’ajuts Universitaris i de Recerca Generalitat de Catalunya (AGAUR, ref.: 2017SGR01020). The DCEXS is a “Unidad de Excelencia María de Maeztu”, funded by the MINECO (ref: MDM-2014-0370).
dc.format.extent18 p.
dc.language.isoeng
dc.publisherMDPI
dc.rightsAttribution 3.0 Spain
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectÀrees temàtiques de la UPC::Informàtica::Sistemes d'informació
dc.subject.lcshData mining
dc.subject.lcshModeling and simulation in science, engineering & technology
dc.subject.lcshToxicology
dc.subject.otherToxicology;
dc.subject.otherDrug safety;
dc.subject.otherTranslational safety assessment
dc.subject.otherData sharing
dc.subject.otherIntegrative knowledge management
dc.subject.otherData mining
dc.subject.otherRead across
dc.subject.otherPredictive modelling
dc.titleThe eTRANSAFE project on translational safety assessment through integrative knowledge management: achievements and perspectives
dc.typeArticle
dc.subject.lemacMineria de dades
dc.identifier.doi10.3390/ph14030237
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.mdpi.com/1424-8247/14/3/237#
dc.rights.accessOpen Access
dc.description.versionPostprint (published version)
local.citation.other237
local.citation.publicationNamePharmaceuticals
local.citation.volume14
local.citation.number3


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