Mostra el registre d'ítem simple
In vitro evaluation of degradable electrospun polylactic acid/bioactive calcium phosphate ormoglass scaffolds
dc.contributor.author | Majchrowicz, Anna |
dc.contributor.author | Roguska, Agata |
dc.contributor.author | Krawczynska, A. |
dc.contributor.author | Lewandowska, Malgorzata |
dc.contributor.author | Martí Muñoz, Joan |
dc.contributor.author | Engel López, Elisabeth |
dc.contributor.author | Castaño Linares, Óscar |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials |
dc.date.accessioned | 2021-03-09T12:43:29Z |
dc.date.available | 2021-03-09T12:43:29Z |
dc.date.issued | 2020-04-24 |
dc.identifier.citation | Majchrowicz, A. [et al.]. In vitro evaluation of degradable electrospun polylactic acid/bioactive calcium phosphate ormoglass scaffolds. "Archives of Civil and Mechanical Engineering", 24 Abril 2020, vol. 20, p. 50:1-50:11. |
dc.identifier.issn | 1644-9665 |
dc.identifier.uri | http://hdl.handle.net/2117/341296 |
dc.description.abstract | Nowadays, the main limitation for clinical application of scaffolds is considered to be an insufficient vascularization of the implanted platforms and healing tissues. In our studies, we proposed a novel PLA-based hybrid platform with aligned and random fibrous internal structure and incorporated calcium phosphate (CaP) ormoglass nanoparticles (0, 10, 20 and 30 wt%) as an off-the-shelf method for obtaining scaffolds with pro-angiogenic properties. Complex morphological and physicochemical evaluation of PLA–CaP ormoglass composites was performed before and after in vitro degradation test in SBF solution to assess their biological potential. The degradation process of PLA–CaP ormoglass composites was accompanied by numerous CaP-based precipitations with extended topography and cauliflower-like shape which may enhance bonding of the material with the bone tissue and accelerate the regenerative process. Random fiber orientation was preferable for CaP compounds deposition upon in vitro degradation. CaP compounds precipitated firstly for randomly oriented composite nonwovens with 20 and 30 wt% addition of ormoglass. Moreover, the preliminary bioactivity test has shown that BSA adsorbed to PLA–CaP ormoglass composites (both aligned and randomly oriented) with 20 and 30 wt% of ormoglass nanoparticles which was not observed for pure PLA scaffolds. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
dc.title | In vitro evaluation of degradable electrospun polylactic acid/bioactive calcium phosphate ormoglass scaffolds |
dc.type | Article |
dc.subject.lemac | Teixit ossi |
dc.contributor.group | Universitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies |
dc.identifier.doi | 10.1007/s43452-020-00052-y |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s43452-020-00052-y |
dc.rights.access | Open Access |
local.identifier.drac | 28881121 |
dc.description.version | Postprint (published version) |
local.citation.author | Majchrowicz, A.; Roguska, A.; Krawczynska, A.; Lewandowska, M.; Martí-Muñoz, J.; Engel, E.; Castaño, Ó. |
local.citation.publicationName | Archives of Civil and Mechanical Engineering |
local.citation.volume | 20 |
local.citation.startingPage | 50:1 |
local.citation.endingPage | 50:11 |
Fitxers d'aquest items
Aquest ítem apareix a les col·leccions següents
-
Articles de revista [398]
-
Articles de revista [734]