Show simple item record

dc.contributor.authorEnshaei, Hamidreza
dc.contributor.authorPuiggalí Jou, Anna
dc.contributor.authorValle Mendoza, Luis Javier del
dc.contributor.authorTuron, Pau
dc.contributor.authorSaperas Plana, Núria
dc.contributor.authorAlemán Llansó, Carlos
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Polímers i Biopolímers
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Enginyeria Biomèdica
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2021-03-09T09:10:05Z
dc.date.issued2020-12-18
dc.identifier.citationEnshaei, H. [et al.]. Nanotheranostic Interface Based on Antibiotic-Loaded Conducting Polymer Nanoparticles for Real-Time Monitoring of Bacterial Growth Inhibition. "Advanced healthcare materials", 18 Desembre 2020, núm. 2001636, p. 1-15.
dc.identifier.issn2192-2640
dc.identifier.urihttp://hdl.handle.net/2117/341219
dc.description.abstractConducting polymers have been increasingly used as biologically interfacing electrodes for biomedical applications due to their excellent and fast electrochemical response, reversible doping–dedoping characteristics, high stability, easy processability, and biocompatibility. These advantageous properties can be used for the rapid detection and eradication of infections associated to bacterial growth since these are a tremendous burden for individual patients as well as the global healthcare system. Herein, a smart nanotheranostic electroresponsive platform, which consists of chloramphenicol (CAM)-loaded in poly(3,4-ethylendioxythiophene) nanoparticles (PEDOT/CAM NPs) for concurrent release of the antibiotic and real-time monitoring of bacterial growth is presented. PEDOT/CAM NPs, with an antibiotic loading content of 11.9 ± 1.3% w/w, are proved to inhibit the growth of Escherichia coli and Streptococcus sanguinis due to the antibiotic release by cyclic voltammetry. Furthermore, in situ monitoring of bacterial activity is achieved through the electrochemical detection of ß-nicotinamide adenine dinucleotide, a redox active specie produced by the microbial metabolism that diffuse to the extracellular medium. According to these results, the proposed nanotheranostic platform has great potential for real-time monitoring of the response of bacteria to the released antibiotic, contributing to the evolution of the personalized medicine.
dc.format.extent15 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshConducting polymers
dc.subject.lcshAntibiotics
dc.subject.lcshElectrochemistry
dc.titleNanotheranostic Interface Based on Antibiotic-Loaded Conducting Polymer Nanoparticles for Real-Time Monitoring of Bacterial Growth Inhibition
dc.typeArticle
dc.subject.lemacPolímers conductors
dc.subject.lemacAntibiòtics
dc.subject.lemacElectroquímica
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
dc.contributor.groupUniversitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.
dc.contributor.groupUniversitat Politècnica de Catalunya. MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques
dc.identifier.doi10.1002/adhm.202001636
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/adhm.202001636
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac30640880
dc.description.versionPostprint (author's final draft)
dc.date.lift2021-12-18
local.citation.authorEnshaei, H.; Puiggali, A.; del Valle, LJ.; Turon, P.; Saperas, N.; Aleman, C.
local.citation.publicationNameAdvanced healthcare materials
local.citation.number2001636
local.citation.startingPage1
local.citation.endingPage15


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain